全身磁共振成像多发性骨髓瘤浸润类型评估预后的价值

发布时间：2018-03-13 23:21

  本文选题：多发性骨髓瘤　切入点：磁共振成像　出处：《中国医学影像学杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的探讨全身磁共振成像(WB-MRI)中多发性骨髓瘤(MM)病灶浸润类型评估患者预后的价值。资料与方法选择2010年1月—2016年12月经病理证实的62例MM患者,行WB-MRI检查前均未进行治疗,将患者WB-MRI病灶浸润类型分为正常型、小结节型、大结节型、混合型、弥漫型,比较不同病灶浸润类型对患者总生存期的影响。结果 62例患者中,正常型5例,小结节型20例,大结节型13例,混合型7例,弥漫型17例。所有患者均随访30.9~47.1个月,中位随访时间39个月,混合型患者的中位总生存期为17.0个月(95%CI 12.6~21.3个月),明显比其他浸润类型患者的中位总生存期43.0个月短(95%CI 33.7~52.3个月),差异有统计学意义(P0.05)。此外,按DS和ISS分期系统评估初诊患者的肿瘤临床分期,其中DS I期6例,Ⅱ期6例,Ⅲ期50例;ISSⅠ期15例,Ⅱ期22例,Ⅲ期25例,WB-MRI病灶浸润类型与临床DS分期、ISS分期间无显著相关(P0.05)。结论 WB-MRI中MM的不同浸润类型对评估患者预后有重要价值。
[Abstract]:Objective to evaluate the prognosis of patients with multiple myeloma (MM) lesions in WB-MRI. Materials and methods 62 patients with MM confirmed by pathology from January 2010 to 2016 were selected and none of them were treated before WB-MRI. Patients with WB-MRI were divided into normal type, small nodular type, large nodular type, mixed type and diffuse type. There were 13 cases of large nodular type, 7 cases of mixed type and 17 cases of diffuse type. All the patients were followed up for 30.9 ~ 47.1 months, with a median follow-up time of 39 months. The median total survival time of patients with mixed type was 17.0 months, 95 CI 12.6U 21.3 months, which was significantly shorter than that of other infiltrating patients with 43.0 months CI 33.7 ~ 52.3 months, and the difference was statistically significant (P 0.05). According to DS and ISS staging system, the clinical staging of newly diagnosed patients was evaluated, including 6 cases of DS stage I, 6 cases of stage 鈪，

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