耐碳青霉烯类肺炎克雷伯菌感染危险因素的Meta分析

发布时间：2018-03-14 05:12

本文选题：耐碳青霉烯类抗生素　切入点：肺炎克雷伯菌　出处：《中华医院感染学杂志》2017年18期 　论文类型：期刊论文

【摘要】：目的分析耐碳青霉烯类肺炎克雷伯菌(CRKP)医院感染的危险因素。方法检索Pubmed、Medline、Web of Science、CNKI、万方、维普、中国生物医学文献等,并辅以文献追溯和手工检索,检索日期从建库至2017年7月1日止公开发表的文献,采用Review maneger5.0软件对纳入的文献数据进行分析,NOS法评价各项研究证据等级,并用Egger法评价发表偏倚。结果共纳入14篇研究,其中英文11篇,中文3篇,研究总样本量为2392例;Meta分析CRKP感染危险因素的比值比(OR)值及其95%CI:碳青霉烯类药物使用5.76(4.20,7.90),ICU 2.17(1.56,3.01),抗菌药物的使用2.54(1.80,3.57),定植9.18(2.82,29.92),侵入性医疗操作3.53(2.57,4.85),手术5.79(2.27,14.77),住院时间4.83(1.64,14.26),机械通气4.65(1.91,11.30),基础疾病3.99(0.24,65.34),使用导尿管9.69(0.24,398.28)。结论碳青霉烯类抗生素的大量使用、入住ICU、抗菌药物的使用、定植、手术、侵入性医疗操作、住院时间、机械通气是感染CRKP的高危因素。
[Abstract]:Objective to analyze the risk factors of nosocomial infection induced by Klebsiella carpenicilli and Klebsiella pneumoniae. Methods PubmedmedMedline Medline of ScienceCor CNKI, Wan Fang, Weip, Chinese biomedical literature were searched, and the literature was traced back and retrieved by hand. From the date of retrieval to July 1st 2017, the literature published publicly was analyzed by Review maneger5.0 software and evaluated by Review maneger5.0 method, and the bias of publication was evaluated by Egger method. The results were included in 14 studies. Chinese and English 11, Chinese 3, The total sample size of the study was 2392 cases of Meta-analysis of the risk factors of CRKP infection.) the ratio of risk factors for CRKP infection and 95 CI were as follows: 5.76 ~ 4.207.90%, 2.17 ~ 1.56 ~ 3.01%, 2.54 ~ 1.80 ~ 3.57, 9.182.82 ~ (29. 922), 3.53 ~ 2.5 ~ 4.85, 5.79 ~ 2.27, hospital stay 4.831.6414.26, ventilating time 4.831.6414.260.The invasive medical operation was 3.53 / 2.2.5 / 4.857.77, respectively, and the hospital stay was 4.831.6414.260.The total sample size of the study was 9.182.8229.922, and the operation was 5.792.270.77, and the hospitalization time was 4.831.6414.260.The time of hospitalization was 4.831.6414.26. 4.65, 1.91, 11.30, 3.99, 0.245.34, and 9.69, 0.24, 398.28, respectively. Conclusion the carbapenem antibiotics are widely used. The high risk factors of CRKP infection were ICU, antibiotics use, colonization, surgery, invasive medical operation, hospital stay and mechanical ventilation.
【作者单位】：南昌大学公共卫生学院;南昌大学第一附属医院院感科;
【基金】：江西省科技厅重点基金资助项目(20152ACG70015)
【分类号】：R446.5

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