NICU鲍曼不动杆菌的医院感染与耐药性分析

发布时间：2018-03-19 02:06

本文选题：新生儿重症监护病房　切入点：鲍曼不动杆菌　出处：《中国感染控制杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的了解新生儿重症监护病房(NICU)鲍曼不动杆菌的临床特征及耐药性。方法对2012年10月—2014年10月某院4个NICU鲍曼不动杆菌医院感染临床分离情况及耐药性进行回顾性分析。结果 4个NICU共收治新生儿11 640例,发生医院感染500例(4.3%),其中鲍曼不动杆菌医院感染51例(10.2%),52例次。鲍曼不动杆菌感染:极早产NICU42例次,早产NICU1例次,足月NICU4例次,儿童外科NICU5例次。4个季节鲍曼不动杆菌医院感染发病率比较,差异具有统计学意义(χ~2=16.05,P0.05),主要发生在春、夏两季。鲍曼不动杆菌对哌拉西林/舒巴坦、头孢吡肟、亚胺培南等β-内酰胺类抗生素以及庆大霉素耐药率较高(90%),对阿米卡星耐药率最低,也高达51.9%。52株鲍曼不动杆菌中,46株为多耐药菌株,3株为广泛耐药菌株。结论 NICU鲍曼不动杆菌医院感染最严重的是极早产NICU,对临床常用抗菌药物均呈现高耐药率。
[Abstract]:Objective to investigate the clinical characteristics and drug resistance of Acinetobacter baumannii in neonatal intensive care unit. Methods the clinical isolation and drug resistance of four NICU Acinetobacter baumannii nosocomial infections in a hospital from October 2012 to October 2014 were reviewed. Results 11 640 newborns were treated in 4 NICU. There were 500 cases of nosocomial infection, including 51 cases of Acinetobacter baumannii nosocomial infection, 52 cases of Acinetobacter baumannii infection. Acinetobacter baumannii infection: very preterm NICU42 cases, premature NICU1 cases, term NICU4 cases. The incidence rate of Acinetobacter baumannii nosocomial infection in four seasons was significantly different (蠂 ~ (2 +) 16.05% P 0.05), which mainly occurred in spring and summer. The effect of Acinetobacter baumannii on piperacillin / sulbactam, cefepime, was significant. Imipenem and other 尾 -lactam antibiotics and gentamicin have a high resistance rate of 90%, and the lowest resistance rate to amikacin. Among the 52 strains of Acinetobacter baumannii, 46 were multidrug resistant strains and 3 were widely resistant strains. Conclusion the most serious nosocomial infection of Acinetobacter baumannii NICU is very early birth.
【作者单位】：陆军总医院附属八一儿童医院;陆军总医院;北京大学公共卫生学院;
【基金】：国家自然科学基金(81170602) 中国博士后科学基金(2013M542472)
【分类号】：R446.5

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