A抗原特异性自身抗体鉴定策略探讨1例
发布时间:2018-03-25 12:03
本文选题:A抗原特异性自身抗体 切入点:ABO血型系统 出处:《中国输血杂志》2017年10期
【摘要】:目的对A抗原特异性自身抗体引起的正反不符进行ABO血型鉴定及经验总结。方法均采用试管法进行血型血清学检测;对ABO血型基因第6、7外显子扩增后进行直接测序。结果血型血清学鉴定正定检出A抗原反定检出抗-A,自身吸收放散证明存在A抗原特异性自身抗体。基因检测结果 A102/A102。结论血型为A型,由A抗原特异性自身抗体引起ABO正反不符至定型困难;A抗原特异性自身抗体引起的ABO正反不符可按照ABO疑难血型三步分析法进行血型鉴定。
[Abstract]:Objective to identify the positive and negative inconsistency caused by A antigen specific autoantibodies and to summarize the experience. Methods the blood group serology was detected by test tube method. The ABO blood group gene exon 6 was amplified and sequenced directly. Results A antigen antigens were detected in positive blood group serology. Autoabsorption and elution proved the existence of A antigen-specific autoantibodies. A102 / A102.Conclusion the blood group is A, The positive and negative ABO incompatibility caused by A antigen-specific autoantibodies and the ABO positive and negative inconsistency caused by A antigen-specific autoantibodies can be identified according to the three-step method of ABO difficult blood group analysis.
【作者单位】: 威海市中心血站;威海四0四医院;青岛市中心血站输血研究所;
【基金】:青岛血站给予的大力支持
【分类号】:R457.11
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本文编号:1663035
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