益生菌对重症感染性肺炎病儿血糖的稳定作用及其机制研究

发布时间：2018-03-29 18:44

本文选题：益生菌　切入点：重症感染性肺炎　出处：《肠外与肠内营养》2017年03期

【摘要】：目的:探讨益生菌对重症感染性肺炎病儿血糖水平的调节及作用机制。方法:前瞻性纳入重症感染性肺炎病儿80例,随机分为两组,对照组给予常规治疗,治疗组采用常规治疗加用益生菌。两组病儿分别于入组当天和治疗第8天监测血糖浓度,并测定血浆硫化氢(H2S)、D-乳酸以及粪便短链脂肪酸(乙酸、丙酸、正丁酸)水平,同时观察两组病儿的血糖变化、波动情况和预后,并进行分析。结果:两组病儿入组当天的各项指标均无显著性差异(P0.05)。治疗第8天时,治疗组病儿血浆H2S浓度和粪便中乙酸、正丁酸水平明显高于对照组(P0.05);同时,治疗组病儿血浆D-乳酸浓度也较对照组明显降低(P0.05)。治疗第8天,治疗组病儿的血糖水平和高波动比例显著低于对照组(32.5%)(P0.05)。治疗组病儿的临床治愈率也明显高于对照组。而且血糖浓度与H2S、乙酸水平呈明显负相关,与D-乳酸浓度呈显著正相关(P0.05)。结论:重症感染性肺炎病儿应用益生菌可调整肠道菌群结构,加强肠道屏障功能,增加血浆H2S的浓度,调节和稳定血糖水平,并改善临床预后。
[Abstract]:Objective: to investigate the regulation and mechanism of probiotics on blood glucose level in children with severe infectious pneumonia. Methods: 80 children with severe infectious pneumonia were prospectively included and randomly divided into two groups, the control group was treated with routine therapy. The treatment group was treated with routine treatment plus probiotics. The blood glucose concentration was monitored on the day of admission and the 8th day of treatment in both groups. The levels of plasma H _ 2S _ 2C _ (2) -lactic acid and fecal short-chain fatty acids (acetic acid, propionic acid, n-butyric acid) were measured. At the same time, the changes of blood glucose, fluctuation and prognosis of the two groups were observed and analyzed. Results: there was no significant difference in the indexes of the two groups on the day of admission (P 0.05). On the 8th day of treatment, the concentration of H2S in plasma and acetic acid in feces were found in the treatment group. The level of n-butyric acid was significantly higher than that of the control group (P 0.05), and the plasma D- lactate concentration in the treatment group was significantly lower than that in the control group. The blood glucose level and the high fluctuating ratio of the children in the treatment group were significantly lower than those in the control group (32.5%). The clinical cure rate of the children in the treatment group was significantly higher than that in the control group, and the blood glucose concentration was negatively correlated with the levels of H _ 2S and acetic acid. Conclusion: probiotics can adjust intestinal flora structure, strengthen intestinal barrier function, increase plasma H2S concentration, regulate and stabilize blood glucose level and improve clinical prognosis in children with severe infectious pneumonia.
【作者单位】：河南省人民医院儿科;
【基金】：河南省医学科技攻关计划项目(201403193)
【分类号】：R459.3;R725.6

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