2014-2016年安徽省滁州市儿童医院临床分离菌耐药性监测

发布时间：2018-03-30 00:33

本文选题：儿童　切入点：耐药性　出处：《中国感染与化疗杂志》2017年06期

【摘要】：目的了解安徽省滁州市儿童医院2014年1月-2016年12月常见病原菌的临床分布及耐药情况。方法回顾性分析2014年1月-2016年12月从各类临床标本中分离菌的分布及耐药性。结果 3年间共分离细菌1 057株,其中革兰阳性菌479株(45.3%);革兰阴性菌578株(54.7%)。排名前5位的细菌分别是:大肠埃希菌(19.6%)、金黄色葡萄球菌(15.9%)、克雷伯菌属(14.4%)、凝固酶阴性葡萄球菌(12.6%)和肺炎链球菌(9.1%)。肺炎链球菌对青霉素均敏感。葡萄球菌属中耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的检出率分别为29.8%和74.4%。葡萄球菌属对达托霉素、利奈唑胺和万古霉素均敏感。肠球菌属中屎肠球菌对多数测试药物的耐药率显著高于粪肠球菌。大肠埃希菌、克雷伯菌属(肺炎克雷伯菌和产酸克雷伯菌)和奇异变形杆菌产超广谱β内酰胺酶菌株的检出率分别为50.2%、32.4%和83.3%。肠杆菌科细菌对碳青霉烯类最敏感,485株肠杆菌科细菌检出12株(2.5%)耐碳青霉烯类的肠杆菌科细菌。铜绿假单胞菌和不动杆菌属对碳青霉烯类最敏感。结论近3年临床分离菌以革兰阴性菌为主,细菌耐药情况较为严峻,应加强对其耐药性监测。
[Abstract]:Objective to investigate the clinical distribution and drug resistance of common pathogens in Chuzhou Children's Hospital, Anhui Province from January 2014 to December 2016. Methods the distribution and drug resistance of bacteria isolated from clinical specimens from January 2014 to December 2016 were retrospectively analyzed. Results A total of 1,057 strains of bacteria were isolated in the past three years. Among them, 479 strains of Gram-positive bacteria and 578 strains of Gram-negative bacteria were identified as follows: Escherichia coli 19.667, Staphylococcus aureus 15.9m, Klebsiella 14.4am, coagulase negative Staphylococcus 12.6) and Streptococcus pneumoniae 9.1ng. The detection rates of MRSAs and MRCNS- resistant methicillin-resistant coagulase negative staphylococci were 29.8% and 74.4%, respectively. The resistance rate of Enterococcus faecium to most tested drugs was significantly higher than that of Enterococcus faecalis. The detection rates of Klebsiella pneumoniae (Klebsiella pneumoniae and Klebsiella acidogenic) and Proteus mirabilis producing extended-spectrum 尾 -lactamases were 32.4% and 83.3% respectively. Enterobacteriaceae is most sensitive to carbapenems and 485 strains of Enterobacteriaceae. Pseudomonas aeruginosa and Acinetobacter were the most sensitive to carbapenem. Conclusion Gram-negative bacteria are the main clinical isolates in recent three years. The situation of bacterial drug resistance is more severe, it is necessary to strengthen the monitoring of drug resistance.
【作者单位】：安徽省滁州市第一人民医院检验科;
【分类号】：R446.5

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