蓝光杀菌关键技术研究与装置微型化设计

发布时间：2018-03-31 18:31

本文选题：胃　切入点：幽门螺旋杆菌　出处：《重庆邮电大学》2016年硕士论文

【摘要】：随着生活节奏的加快,越来越多的人受消化道疾病的困扰。寄生于人体胃区的幽门螺旋杆菌是引起诸多消化道疾病的元凶,而目前主要采用药物来治疗菌该类疾病。但药物杀菌根除率不高,且随着抗菌药物的滥用,细菌的耐药性越来越强。蓝光杀菌作为一种物理杀菌方法,具有高效、安全、细菌不会产生抗性等优点。体外与临床实验研究表明,特定波长的蓝光能够有效杀死幽门螺杆菌,根除率高。目前,该技术只局限于在临床实验,且实验设备存在体积大、有创等不足。本课题研究了一种针对胃区幽门螺旋杆菌的微型化杀菌技术,改变了光源进入人体胃区光疗的方式,具有体积小、无创的特性。本文主要工作包括如下:1.讨论了空腹期胃区光疗模型并分析了胃运动对其影响,仿真了光疗光源。通过对胃结构形态及运动模式分析,论证了空腹期胃腔在不同相运动模式下对光疗模型的影响与光源设计。最后,对LED灯组光源进行了仿真。2.设计了基于LED的微型化蓝光杀菌装置。该微型化杀菌装置主要由LED光疗模块、pH传感、主控与无线通信模块、电源管理模块等构成。该装置采用基于pH传感的启停光疗方案,通过对装置在消化道位置追踪,实现工作状态调控。3.通过实验测量数据,测试了pH传感器的测量精度,并拟合了其测量曲线。同时测试其响应时间与启停功能,结果显示符合设计要求。针对测量干扰,提出基于集合经验模态分解自动重构的抗干扰算法,以提高抗干扰能力与测量准确性。4.通过实验测试,验证了光疗模块在不同功率输出模式下系统工作效率,测定输出能量是否符合设计要求。同时,测试了各功能模块的功耗,分析了功耗比的合理性。结果表明,各项参数符合本文设计要求。本课题研究的蓝光杀菌技术,其主要目的是在空腹期对胃腔幽门螺旋杆菌进行杀灭,达到治愈疾病的效果,具有微型化、无创等优点。对该技术进一步研究与完善,将极大提高蓝光杀菌技术在临床的应用价值。
[Abstract]:As the pace of life accelerates, more and more people suffer from digestive tract diseases. Helicobacter pylori, parasitic in the human stomach, is responsible for many digestive tract diseases. But the bactericidal eradication rate is not high, and with the abuse of antimicrobial agents, bacterial resistance is becoming stronger and stronger. As a physical sterilization method, blue ray sterilization has high efficiency and safety. Studies in vitro and in clinical trials show that specific wavelengths of blue light can effectively kill Helicobacter pylori and have a high eradication rate. At present, the technique is limited to clinical trials, and the experimental equipment has a large volume. In this paper, a miniaturized bactericidal technique for Helicobacter pylori in the gastric region was studied, which changed the way of light source entering the gastric area of the human body and had a small size. The main work of this paper is as follows: 1.Discusses the model of phototherapy of stomach area in fasting period, analyzes the influence of gastric movement on it, and simulates the light source of phototherapy. The effect of fasting gastric cavity on phototherapy model and the design of light source in different phase motion mode are demonstrated. Finally, The light source of LED lamp set is simulated. 2. The miniaturized blue light sterilizing device based on LED is designed. The miniaturized sterilizing device is mainly composed of pH sensing module of LED phototherapy module, main control module and wireless communication module. The device adopts the scheme of starting and stopping light therapy based on pH sensor, and realizes the working state control by tracking the position of the device in the digestive tract. The measuring accuracy of the pH sensor is tested through the experimental measurement data. At the same time, the response time and the function of starting and stopping are tested, and the results show that it meets the design requirements. An anti-jamming algorithm based on the set empirical mode decomposition automatic reconstruction is proposed for the measurement interference. In order to improve anti-interference ability and accuracy of measurement .4.Through experimental tests, the system efficiency of phototherapy module under different power output modes is verified, and the output energy is measured to meet the design requirements. At the same time, the power consumption of each functional module is tested. The rationality of power consumption ratio is analyzed. The results show that the parameters meet the requirements of the design of this paper. The main purpose of the blue ray sterilization technique is to kill Helicobacter pylori in the stomach cavity on an empty stomach, so as to cure the disease. It has the advantages of miniaturization, noninvasive and so on. Further research and improvement of this technology will greatly improve the application value of blue ray sterilization technology in clinic.
【学位授予单位】：重庆邮电大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R454

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