脓毒症早期采用心肌标志物诊断心功能障碍的预后评估

发布时间：2018-03-31 22:34

本文选题：脓毒症　切入点：心脏功能障碍　出处：《实用医学杂志》2017年10期

【摘要】：目的:研究早期脓毒症患者采用心肌标志物联合BNP预测评估心功能障碍的应用价值。方法:66例脓毒症患者入院后的3~5 d左室射血分数LVEF50%与LVEF50%分为两组,分别监测两组患者0、3、5、12 d的LVEF值、BNP及TNI。结果:左室射血分数LVEF50%与LVEF50%两组:3、5 d时BNP值心脏损伤显著高于心脏非损伤;心脏损伤组EF值与TNI值呈负相关,患者入院后的3~5 dEF数值与血肌钙蛋白水平呈负相关;患者入院后的第12天血肌钙蛋白Ⅰ的浓度与EF值呈负相关。TNI可直接反映患者心脏功能状态;BNP值在第5天与APACHEⅡ的评分呈显著正相关性;结论:TNI与BNP均可直接反映脓毒症患者心功能障碍,且BNP与TNI结合可有效评估严重脓毒症与脓毒症休克患者的临床治疗,具有较高的预后评估意义。
[Abstract]:Objective: To study the early sepsis patients with cardiac markers combined with BNP predictive evaluation of application value for cardiac dysfunction. Methods: 66 cases of hospitalized patients with sepsis after 3~5 d left ventricular ejection fraction LVEF50% and LVEF50% were divided into two groups, respectively LVEF 0,3,5,12 D monitoring in two groups, BNP and TNI. results. The left ventricular ejection fraction LVEF50% and LVEF50% two groups: 3,5 D BNP heart injury was significantly higher than that of non cardiac injury; cardiac injury in group EF was negatively correlated with TNI value was negatively correlated with serum 3~5 levels of troponin dEF values in patients after admission; concentration and EF patients admitted to the hospital after twelfth days of blood troponin I the value is negatively related to.TNI can directly reflect the state of cardiac function patients; BNP values showed a significant positive correlation in fifth days and APACHE II score; conclusion: TNI and BNP can directly reflect the sepsis patients with heart dysfunction, and BNP combined with TNI can effectively assess the serious The clinical treatment of sepsis and septic shock is of high prognostic significance.

【作者单位】：温岭市第一人民医院重症医学科;
【基金】：浙江省医药卫生科技项目(编号:2017KY169) 浙江省台州市科技局项目(编号:1601KY45)
【分类号】：R459.7

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