红花黄色素治疗严重脓毒症患者的心肌损伤

发布时间：2018-04-01 20:12

本文选题：红花黄色素　切入点：严重脓毒症　出处：《中成药》2017年04期

【摘要】：目的观察红花黄色素safflower yellow治疗严重脓毒症心肌损伤患者的疗效。方法采用前瞻性研究方法,选择我院2013年1月至2016年3月收治的92例严重脓毒症心肌损伤患者,按数字表法随机分成对照组和观察组各46例,对照组给予常规治疗,观察组在常规治疗基础上给予红花黄色素治疗,连续应用2周。治疗前及治疗后6、72 h,2组患者均检测心型脂肪酸结合蛋白(H-FABP)、肌酸激酶(CK)和肌酸激酶同工酶(CK-MB)水平的变化,同时观察治疗前后左心室射血分数(LVEF)水平、序贯器官功能衰竭评分(SOFA)、记录重症监护病房(ICU)住院时间及主要心脏不良事件(MACE)发生率情况,记录患者28 d生存情况。结果治疗前2组H-FABP、CK、CK-MB水平及LVEF和SOFA评分比较均无统计学意义。治疗后6 h,观察组H-FABP、CK、CK-MB水平和SOFA评分较均较对照组低,2组患者H-FABP、CK和CK-MB水平均较治疗前升高,SOFA评分较治疗前降低。治疗后72 h,2组HFABP、CK、CK-MB和SOFA评分较治疗后6 h降低,观察组SOFA评分低于对照组,2组H-FABP、CK和CK-MB水平比较差异无统计学意义。观察组MACE发生率低于对照组,治疗后LVEF和ICU住院时间无差异。观察组28 d生存率明显高于对照组(76.08%,35/46 vs 54.35%,25/46;χ~2=4.529,P=0.033)。脓毒症患者入院血H-FABP水平与其LVEF呈负相关(r=-0.270,P=0.009)。结论红花黄色素对脓毒症心肌损伤患者的疗效优于常规治疗,可以在一定程度上改善患者预后。
[Abstract]:Objective to observe the efficacy of safflower yellow safflower yellow in treating severe sepsis with myocardial injury.Methods 92 patients with severe sepsis myocardial injury admitted in our hospital from January 2013 to March 2016 were randomly divided into control group (n = 46) and observation group (n = 46).The observation group was treated with safflower yellow on the basis of routine treatment for 2 weeks.The levels of cardiac fatty acid binding protein (H-FABPU), creatine kinase (CK) and creatine kinase isoenzyme (CK-MBB) were detected before and after treatment, and the left ventricular ejection fraction (LVEF) was observed before and after treatment.Sequential organ failure score (SOFAA) was used to record the hospitalization time of ICU and the incidence of major adverse cardiac events (MACEE) in intensive care unit (ICU), and to record the survival status of the patients for 28 days.Results there was no significant difference in CK-MB level, LVEF and SOFA scores between the two groups before treatment.At 6 hours after treatment, the levels of CK-MB and SOFA in the observation group were lower than those in the control group. The levels of CK and CK-MB in the two groups were lower than those in the control group.The CK-MB and SOFA scores of HFABPP-CK-MB and SOFA in the two groups were lower than those in the control group at 72 h after treatment. The SOFA scores in the observation group were lower than those in the control group (P < 0.05). There was no significant difference in the levels of H-FABPU CK and CK-MB between the two groups.The incidence of MACE in the observation group was lower than that in the control group. There was no difference in the hospitalization time between LVEF and ICU after treatment.The 28 day survival rate in the observation group was significantly higher than that in the control group (76.08 vs 54.35 / 46 vs 54.3525 / 46);There was a negative correlation between H-FABP level and LVEF in sepsis patients.Conclusion the therapeutic effect of safflower yellow on septic myocardial injury is better than that of routine therapy, and it can improve the prognosis to some extent.
【作者单位】：河北医科大学附属哈励逊国际和平医院急救医学部;河北医科大学附属哈励逊国际和平医院重症医学科;
【基金】：衡水市科学技术研究与发展计划项目(15019)
【分类号】：R459.7

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