三维斑点追踪技术评价蒽环类药物对淋巴瘤患者左室心肌功能损害的价值

发布时间：2018-04-05 03:01

  本文选题：三维斑点追踪成像技术　切入点：淋巴瘤　出处：《安徽医学》2017年04期

【摘要】：目的探讨三维斑点追踪成像(3D-STI)技术评价蒽环类药物对弥漫大B细胞淋巴瘤(DLBCL)患者早期左心室功能损害的价值。方法选取2014年12月至2016年10月安徽医科大学第一附属医院行蒽环类药物化疗的DLBCL患者28例,分别于化疗前及化疗2、4、6个周期(即累计剂量达100、200、300 mg/m2)后24~48 h内行二维超声心动图及3D-STI检查,获取常规二维超声心动图数值及左心室整体面积应变(GAS)、整体纵向应变(GLS)、整体圆周应变(GCS)、整体径向应变(GRS),并进行统计学分析。结果 GAS、GLS在化疗4个周期[(-28.66±2.67)%,(-16.49±1.94)%]及6个周期[(-25.14±2.73)%,(-15.12±1.97)%]时,与化疗前[(-34.86±2.90)%,(-18.36±2.32)%]及化疗2个周期[(-34.05±2.09)%,(-17.75±1.91)%]时比较显著降低,差异有统计学意义(P0.05)。Pearson相关分析显示,GAS与多柔比星累计剂量呈负相关(r=-0.815,P0.05)。整个化疗进程中,GCS、GRS无明显变化。结论 GAS对DLBCL患者蒽环类药物化疗后出现早期左心室功损害的敏感性较高。3D-STI技术可以发现早期蒽环类药物所致的心脏毒性。
[Abstract]:Objective to evaluate the effect of anthracycline on early left ventricular dysfunction in patients with diffuse large B cell lymphoma (DLBCLL) by three dimensional speckle tracking imaging (3D-STI).Methods from December 2014 to October 2016, 28 patients with DLBCL received anthracycline chemotherapy in the first affiliated Hospital of Anhui Medical University.Two dimensional echocardiography and 3D-STI were performed before chemotherapy and within 24 hours after chemotherapy for 6 cycles (i.e. cumulative dose of 100200300 mg / m ~ 2).The values of conventional two-dimensional echocardiography and the global area strain of left ventricle (GASA), the global longitudinal strain (GLSN), the global circumferential strain (GCS) and the global radial strain (GRS) were obtained and analyzed statistically.缁撴灉 GAS,GLS鍦ㄥ寲鐤，

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