我院耐碳青霉烯类革兰氏阴性杆菌检出率与药物消耗量的相关性分析

发布时间：2018-04-14 19:15

本文选题：耐碳青霉烯类 + 革兰氏阴性杆菌　；参考：《中国药房》2017年20期

【摘要】：目的:为规范临床碳青霉烯类抗菌药物的使用和控制耐药菌感染提供参考。方法:回顾性分析我院2011-2016年3种耐碳青霉烯类革兰氏阴性杆菌的检出情况,并统计碳青霉烯类抗菌药物的消耗量、目标治疗率和用药疗程,采用Pearson检验考察耐药菌检出率与碳青霉烯类抗菌药物消耗量的相关性。结果:2011-2016年,我院共检出耐碳青霉烯类鲍曼不动杆菌(CRAB)1 222株、耐碳青霉烯类铜绿假单胞菌(CRPA)655株、耐碳青霉烯类大肠埃希菌(CRE)53株,检出率分别由2011年的23.88%、8.92%、0.09%上升至2016年的80.34%、35.74%、0.97%;我院使用的碳青霉烯类抗菌药物品种主要为亚胺培南和美罗培南,其消耗量分别由4 222、145 g上升至7 218、4 387 g,两者的目标治疗率均低于60%,用药疗程14 d的患者比例均超过65%。CRAB、CRPA、CRE的检出率与碳青霉烯类抗菌药物的消耗量均呈正相关(r0.9,P0.05)。结论:我院耐碳青霉烯类革兰氏阴性杆菌的检出率及药物消耗量均逐年增加,且两者具有一定的相关性。我院碳青霉烯类抗菌药物的目标治疗率较低,且用药疗程较长,临床使用有待规范。临床应严格遵循用药指征合理选用碳青霉烯类抗菌药物,以减少耐药菌株的产生。
[Abstract]:Objective: to provide a reference for standardizing the use of carbapenem antibiotics and controlling the infection of resistant bacteria.Methods: the detection of three carbapenem resistant gram-negative bacilli in our hospital from 2011 to 2016 was analyzed retrospectively, and the consumption of carbapenem antibiotics, the target treatment rate and the course of treatment were analyzed.The correlation between the detection rate of resistant bacteria and the consumption of carbapenes was investigated by Pearson test.Results from 2011 to 2016, 1 222 strains of Acinetobacter baumannii, 655 strains of Pseudomonas aeruginosa and 53 strains of Escherichia coli were identified in our hospital.The detection rate increased from 23.888.92% in 2011 to 80.34% in 2016 and 0.97% in 2016. The main kinds of carbapenem antibiotics used in our hospital are imipenem and meropenem.The consumption increased from 4 222145 g to 7 218 g to 4 387 g, the target treatment rate of both was lower than 60, and the proportion of patients treated for 14 days was more than 65. The detection rate of CRPA CRE was positively correlated with the consumption of carbapenes (P 0. 05).Conclusion: the detection rate and drug consumption of carbapenem resistant gram-negative bacilli in our hospital are increasing year by year, and there is a certain correlation between them.The target treatment rate of carbapenem antibiotics in our hospital is low, the course of treatment is longer, and the clinical use needs to be standardized.Clinical use of carbapenem antibiotics should be followed strictly in order to reduce the production of resistant strains.
【作者单位】：东莞东华医院药学部;
【分类号】：R446.5

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