MRI分析阿尔茨海默病进程中海马头、体、尾部体积改变

发布时间：2018-04-18 10:26

本文选题：阿尔茨海默病 + 轻度认知障碍　；参考：《中国医学影像技术》2017年06期

【摘要】：目的探讨阿尔茨海默病(AD)进程中,海马头、体、尾部形态学改变。方法对AD、轻度认知障碍(MCI)患者各30例(AD组、MCI组)及30名正常老年人(正常对照组)行颅脑MRI扫描。基于MRI扫描图像将海马头、体、尾部进行分段,并测量其体积。比较AD组、MCI组、正常对照组海马体积整体差异及头、体、尾部体积差异。分析海马体积与各神经评定量表评分的相关性。结果 3组中,左侧海马总体积及头、体、尾部体积均大于右侧(P均0.05)。3组间左、右海马总体积比较,AD组小于正常对照组(P均0.01)及MCI组(P均0.05),MCI组小于正常对照组(P均0.05)。与正常对照组比较,AD组左、右海马头、体、尾部体积均减小(P均0.05),MCI组左海马头、体部及右海马头部体积减小(P均0.05)。AD组左、右海马头、体部体积均小于MCI组(P均0.05)。简易智能状态检查表(MMSE)评分与双侧海马头、体、尾部体积及总体积均呈正相关。除左海马尾部外,双侧海马头、体、尾部体积及总体积均与日常生活能力量表(ADL)评分及临床痴呆分级量表(CDR)评分呈负相关,均与蒙特利尔认知评估量表(MoCA)评分呈正相关。结论 AD患者双侧海马体积明显缩小,MCI患者海马体部、尾部萎缩不明显,但海马头部体积明显缩小。
[Abstract]:Objective to investigate the morphological changes of the head, body and tail of hippocampus in the process of Alzheimer's disease (AD).Methods craniocerebral MRI scans were performed in 30 patients with AD and 30 patients with mild cognitive impairment (MCI) and 30 normal elderly (normal control group).The head, body and tail of hippocampus were segmented and the volume was measured based on MRI scanning images.The differences of hippocampal volume, head, body and tail volume were compared between AD group and normal control group.The correlation between hippocampal volume and the scores of each nerve rating scale was analyzed.Results in the three groups, the total volume of left hippocampus, head, body and tail were all larger than that of the right group (P 0.05.3), the total volume of right hippocampus in AD group was lower than that in the normal control group (P 0.01), and the total volume of left hippocampus, head, body and tail of MCI group was lower than that of normal control group (P < 0.05).Compared with the normal control group, the volume of left and right hippocampal head, body and tail of AD group were all decreased (P < 0.05). The volume of body and right hippocampus head in 0.05).AD group was lower than that in MCI group (P < 0.05).MMSE scores were positively correlated with bilateral hippocampal head, body, tail volume and total volume.With the exception of left hippocampus tail, bilateral hippocampal head, body, tail volume and total volume were negatively correlated with ADL score and clinical dementia rating scale (CDRL), and were positively correlated with Montreal Cognitive Assessment scale (MMA).Conclusion bilateral hippocampal volume was significantly reduced in AD patients with MCI, and the tail atrophy was not obvious, but the hippocampal head volume was significantly reduced.
【作者单位】：重庆医科大学解剖学教研室;重庆医科大学附属第一医院放射科;
【分类号】：R445.2;R749.16

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