利用事件相关电位探索三种听觉Oddball范式脑加工机制的研究

发布时间：2018-04-21 05:38

本文选题：事件相关电位 + P　；参考：《中国康复医学杂志》2017年06期

【摘要】：目的:开发一组新的听觉Oddball范式,通过事件相关电位观察其在健康受试者中的脑加工反应。方法:社会招募健康志愿者15名(男8名,女7名,平均年龄40±9岁),分别进行纯音-正名(TS),其他名字-正名(OS)和反名-正名(RS)三组难度依次增大的听觉Oddball范式的事件相关电位检查,分析比较各组MMN和P300潜伏期和波幅的差异。结果:三组实验范式在所有健康志愿者中均诱发得到失匹配负波(mismatch negativity,MMN)和P300,TS组MMN和P300的潜伏期最短,OS组次之,RS组最长(P0.05),但OS组和RS组统计学分析无显著性差异(P0.05);MMN的波幅TS组最大,OS组次之,RS组最小(P0.05),但OS组和RS组统计学分析无显著性差异(P0.05);各组之间P300波幅比较未发现显著性差异(P0.05)。结论:三组听觉Oddball实验范式有一定的区分难度,有望进一步应用于植物状态/无反应觉醒综合征患者和最小意识状态患者的鉴别诊断和预后预测。
[Abstract]:Objective: to develop a new group of auditory Oddball paradigms to observe the brain processing response in healthy subjects through the event related potential. Methods: 15 healthy volunteers (8 men, 7 women, 40 + 9 years old) were recruited from the society, and the pure tone positive name (TS), the other names (OS) and the anti name positive name (RS) three groups were increased in order of difficulty. The difference between the latency and amplitude of MMN and P300 in each group was analyzed and compared with the event related potential test of Oddball paradigm. Results: the three groups of experimental paradigms induced the mismatched negative wave (mismatch negativity, MMN) and P300 in all healthy volunteers. The latency of MMN and P300 in TS group was the shortest. There was no significant difference in the study analysis (P0.05), the largest of the MMN group TS group, the OS group and the RS group (P0.05), but there was no significant difference between the OS group and the RS group (P0.05). The P300 wave amplitude between the groups did not find a significant difference (P0.05). Conclusion: the three groups of auditory perception Oddball experimental paradigms are difficult to distinguish, and are expected to be further applied. Differential diagnosis and prognosis prediction of patients with vegetative state / non response waking syndrome and minimally conscious patients.

【作者单位】：首都医科大学宣武医院康复医学科;
【基金】：国家自然科学基金项目(81371194,30770714,81171024) 北京市新世纪百千万人才工程资助项目
【分类号】：R49

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