儿童下呼吸道临床分离菌的分布及耐药性

发布时间：2018-04-26 22:10

本文选题：儿童 + 下呼吸道　；参考：《中国感染与化疗杂志》2017年05期

【摘要】：目的研究儿童下呼吸道临床分离菌的分布及其对常用抗菌药物的耐药性,为临床治疗及流行病学提供参考依据。方法收集2014年9月-2016年9月0~5岁下呼吸道感染患儿病例资料进行回顾性分析。结果 4 815例患儿下呼吸道标本细菌培养阳性1 582例,检出率为32.86%。共分离出菌株1 614株,依次为流感嗜血杆菌(9.66%)、肺炎链球菌(7.12%)、卡他莫拉菌(5.15%)等。细菌在不同年龄段、不同季节检出率差异有统计学意义(P0.01)。流感嗜血杆菌、卡他莫拉菌和肺炎链球菌对头孢噻肟耐药率较低,均20%;大肠埃希菌和肺炎克雷伯菌对头孢替坦、亚胺培南和哌拉西林-他唑巴坦耐药率均10%;金黄色葡萄球菌对苯唑西林耐药率20%。结论流感嗜血杆菌是四川省内江地区儿童下呼吸道分离的主要病原菌,其次是肺炎链球菌和卡他莫拉菌,在不同年龄段、不同季节检出率有差异。治疗时应根据药敏结果合理选择抗菌药物,减少耐药菌产生。
[Abstract]:Objective to study the distribution of clinical bacteria isolated from children's lower respiratory tract and their resistance to common antimicrobial agents, and to provide reference for clinical treatment and epidemiology. Methods the data of 5 years old children with lower respiratory tract infection from September 2014 to September 2016 were retrospectively analyzed. Results 1 582 cases of lower respiratory tract specimens were positive in 4 815 cases, the positive rate was 32.86%. A total of 1,614 strains were isolated, followed by Haemophilus influenzae 9.66, Streptococcus pneumoniae 7.12 and Salmonella katamora 5.15. The positive rate of bacteria in different age groups and different seasons was significantly different (P 0.01). Haemophilus influenzae, Streptococcus pneumoniae and Haemophilus influenzae had lower resistance to cefotaxime (20%), Escherichia coli and Klebsiella pneumoniae (Klebsiella pneumoniae) were resistant to cefotaxime. The resistance rates of imipenem and piperacillin-tazobactam were 10 and 20 respectively. Conclusion Haemophilus influenzae is the main pathogen isolated from the lower respiratory tract of children in Neijiang area of Sichuan Province, followed by Streptococcus pneumoniae and Mora carinii. The detection rate of Haemophilus influenzae is different in different ages and seasons. Antimicrobial agents should be reasonably selected according to the results of drug sensitivity in order to reduce the production of drug-resistant bacteria.
【作者单位】：西南医科大学基础医学院病原生物学教研室;内江市第一人民医院检验科;西南医科大学附属医院检验科;内江市第二人民医院检验科;
【基金】：2012年国际医学研究基金(亚洲区)临床微生物学专项基金(CNSC-J2011-A330-ZB016) 四川省学术和技术带头人培养基金(15031) 四川大学与泸州市人民政府战略合作项目(2013CDLZ-S15)
【分类号】：R446.5;R725.6

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