2010-2016年重庆一医院肠道外气单胞菌耐药性分析

发布时间：2018-04-27 00:22

本文选题：气单胞菌 + 耐药性　；参考：《中国感染与化疗杂志》2017年06期

【摘要】：目的了解近7年间重庆一医院肠道外分离的气单胞菌对临床常用药物耐药情况,为临床合理选择抗菌药物提供客观依据。方法回顾性分析2010|2016年住院患者肠道外分离的非重复气单胞菌株的临床分布特征并对14种抗菌药物的体外药敏结果进行判读,采用WHONET5.6软件进行数据分析。结果 2010|2016年共分离肠道外非重复气单胞菌230株,以嗜水气单胞菌最为常见,占83.0%,其次为维氏气单胞温和生物变种,占14.8%。主要分离自伤口分泌物,其次为胆汁和尿液。气单胞菌对甲氧苄啶-磺胺甲唑耐药最为严重,耐药率为46.8%,其次为头孢曲松(37.0%)和头孢呋辛(28.8%),对氨曲南、头孢吡肟、环丙沙星的耐药率在10%以上。对哌拉西林-他唑巴坦、头孢西丁、左氧氟沙星、阿米卡星和庆大霉素以及碳青霉烯类抗菌药物的耐药率低于10%。其中,对亚胺培南耐药率为4.0%,对美罗培南耐药率为1.7%。除对哌拉西林-他唑巴坦、亚胺培南和阿米卡星外,嗜水气单胞菌对其他抗菌药物耐药率均高于维氏气单胞温和生物变种。尚未发现维氏气单胞温和生物变种对美罗培南耐药菌株。结论该院临床分离气单胞菌肠道外感染以嗜水气单胞菌和维氏气单胞温和生物变种为主。气单胞菌科不同菌种对抗生素的耐药率有差别。由于气单胞菌对甲氧苄啶-磺胺甲唑和第三代头孢菌素耐药较为严重,临床应慎重使用。
[Abstract]:Objective to investigate the antimicrobial resistance of Aeromonas isolated from intestinal tract in a hospital of Chongqing in recent seven years and to provide objective evidence for rational selection of antimicrobial agents in clinic. Methods the clinical distribution characteristics of non-repeated Aeromonas isolated from intestinal tract of inpatients in 2010 and 2016 were analyzed retrospectively. The results of drug sensitivity of 14 antimicrobial agents in vitro were analyzed. The data were analyzed by WHONET5.6 software. Results A total of 230 strains of non-repeating Aeromonas were isolated from the intestine in 2010 and 2016. Aeromonas hydrophila was the most common bacteria, accounting for 83.0%, followed by Vickers aeromonas and biological variety 14.8%. Mainly isolated from wound secretion, followed by bile and urine. Aeromonas had the most serious resistance to trimethoprim-sulfamethazolium with a drug resistance rate of 46.8, followed by ceftriaxone 37.0) and cefuroxime 28. 8%. The resistance rates to aztreonam, cefepime and ciprofloxacin were more than 10%. Resistance to piperacillin-tazobactam, cefoxitin, levofloxacin, amikacin, gentamicin and carbapenems was lower than 10. The resistance rate to imipenem was 4.0 and to meropenem was 1.7. With the exception of piperacillin-tazobactam imipenem and amikacin the antimicrobial resistance of Aeromonas hydrophila to other antimicrobial agents was higher than that of Aeromonas Vickers and Amikacin. Vickers Aeromonas and Vickers Gymomonas were not found to be resistant to meropenem. Conclusion Aeromonas hydrophila and Aeromonas Vickers and mild biologic varieties are the main pathogens of extraintestinal infection of Aeromonas aeromonas isolated in our hospital. The resistance rates of different strains of Aeromonas to antibiotics were different. Due to the serious resistance of Aeromonas to trimethoprim-sulfamethazol and third generation cephalosporins, clinical use should be careful.
【作者单位】：重庆医科大学附属第一医院检验科;
【基金】：重庆市科学技术委员会基础与前沿一般项目(cstc2016jcyj A0248)
【分类号】：R446.5

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