磁共振动态增强扫描定量分析方法评价肺部肿块良恶性初步研究

发布时间：2018-04-28 13:40

  本文选题：肺肿瘤 + 活组织检查　； 参考：《中国临床医学影像杂志》2017年07期

【摘要】：目的:探讨动态增强磁共振(DCE-MRI)扫描定量参数测定对鉴别肺部肿块良恶性的可行性。方法:77例肺部肿块患者行3.0T MR动态增强扫描,并经手术或穿刺活检病理证实,测量定量参数:容量转移常数(K~(trans))、速率常数(K_(ep))和血管外细胞外间隙容积比(v_e),分别对良性病变、恶性病变定量参数值进行统计学分析;最后绘制ROC曲线。结果 :恶性病变组:低分化腺癌K~(trans)、K_(ep)、v_e均值分别为(0.270±0.089)min~(-1)、(0.926±0.475)min~(-1)、0.340±0.144,低分化鳞癌分别为(0.268±0.066)min~(-1)、(0.997±0.464)min~(-1)、0.293±0.091,小细胞癌均值为(0.238±0.074)min~(-1)、(0.617±0.369)min~(-1)、0.412±0.312;良性病变组K~(trans)、K_(ep)、v_e均值分别为(0.190±0.084)min~(-1)、(0.569±0271)min~(-1)、0.392±0.207。良、组行独立样本t检验,K~(trans)、K_(ep)值均有统计学差异(P值均0.05),v_e值无统计学差异(P值0.05),良性病灶组分别与低分化腺癌、低分化鳞癌组行成组设计方差分析,K~(trans)及K_(ep)差异均有统计学意义(P值均0.05),v_e均无统计学差异(P值均0.05);低分化腺癌与低分化鳞癌K~(trans)、K_(ep)、v_e差异均无统计学意义(P值均0.05)。良性病灶组及恶性病灶组ROC曲线下面积分别为0.741、0.715,敏感性分别为88.4%、39.5%;特异性分别为54.2%、95.8%。结论 :DCE-MRI定量参数K~(trans)、K_(ep)值鉴别诊断肺部肿块具有可行性,有助于对肺癌及肺部良性病灶进行鉴别。
[Abstract]:Objective: to investigate the feasibility of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters in differentiating benign and malignant pulmonary masses. Methods 77 patients with pulmonary mass underwent dynamic contrast enhanced 3.0T Mr scan, confirmed by operation or biopsy and pathology. Quantitative parameters were measured: volume transfer constant, rate constant, and extracellular space volume ratio, respectively, for benign lesions. The quantitative parameters of malignant lesions were analyzed statistically. Finally, ROC curves were drawn. 缁撴灉 :鎭舵，

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