脓毒血症患者血清褪黑素水平检测用于预后评估的临床价值

发布时间：2018-05-02 15:16

  本文选题：褪黑素 + 脓毒血症　； 参考：《东南大学学报(医学版)》2017年03期

【摘要】：目的:通过检测脓毒血症患者褪黑素水平,探讨其与病情严重程度、炎症相关指标和死亡率的相关性。方法:收入脓毒血症患者64例,采集其临床信息和血清样品。根据第30天生存与否将患者分为生存组(43例)和死亡组(21例)。应用酶联免疫吸附(ELISA)法检测血清褪黑素、干扰素-γ(IFN-γ)及白介素-4(IL-4)水平。结果:血清褪黑素水平生存组为(13.19±0.807)pg·ml~(-1),死亡组为(18.53±1.257)pg·ml~(-1),两组间差异有统计学意义(P0.001)。褪黑素水平15 pg·ml~(-1)患者的30 d生存率显著低于褪黑素水平15 pg·ml~(-1)者(P=0.002),且褪黑素水平是30 d死亡率的独立危险因子(P=0.001)。褪黑素水平与胆红素、乳酸、序贯器官衰竭估计(SOFA)评分、急性生理与慢性健康Ⅱ(APACHEⅡ)评分及IL-4评分呈显著正相关,与住院时间及机械通气天数呈显著负相关。结论:脓毒血症患者的褪黑素水平是死亡率的独立危险因子,对其检测有较高的临床应用价值。
[Abstract]:Objective: to investigate the correlation of melatonin level with severity of disease, inflammation related index and mortality rate in patients with sepsis. Methods: clinical information and serum samples were collected from 64 patients with sepsis. Patients were divided into survival group (n = 43) and death group (n = 21). Serum melatonin, interferon- 纬 (IFN- 纬) and interleukin-4 (IL-4) were detected by Elisa. Results: the serum melatonin level in survival group was 13.19 卤0.807)pg / ml ~ (-1) and that in death group was 18.53 卤1.257)pg / ml ~ (-1). The difference between the two groups was statistically significant (P 0.001). The 30-day survival rate of patients with melatonin level (15 PG / ml) was significantly lower than that of patients with melatonin level (15 PG / ml -1), and melatonin level was an independent risk factor for 30 day mortality. The level of melatonin was positively correlated with bilirubin, lactic acid, sequential organ failure estimation score, acute physiology and chronic health 鈪，

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