遗忘型轻度认知障碍脑灰质扩散张量成像特征研究

发布时间：2018-05-05 11:41

本文选题：阿尔茨海默病 + 遗忘型轻度认知障碍　；参考：《医学研究生学报》2017年11期

【摘要】：目的既往研究多是利用扩散张量成像(DTI)研究脑白质特性以评估遗忘型轻度认知障碍(aMCI)和阿尔茨海默病(AD)患者。文中应用DTI中的平均扩散率(MD)评估aMCI和AD患者灰质微观结构完整性的损伤特征,从而判断其转化规律。方法回顾性分析南京大学医学院附属鼓楼医院2014年1月至2016年12月期间30例符合Petersen标准的aMCI患者(aMCI组)、30例AD患者(AD组)以及30例正常对照组(CN组)测量的全脑灰质MD值,构建灰质水分子平均扩散率网络,计算小世界网络特性,并与神经心理学评分进行相关性分析。结果与CN组相比,aMCI和AD组的灰质水分子平均扩散率网络显示出异常的小世界特性,即聚集程度较高和路径长度较长,反映了灰质微结构的损伤,且aMCI患者网络的平均连接度低于CN组,但高于AD组,差异均有统计学意义(P0.05)。包括双侧海马和边缘系统的11个枢纽脑区灰质MD值和蒙特利尔认知评估量表得分呈负相关(P0.05)。结论 aMCI脑灰质的水分子扩散特征有助于发现AD前期患者,并反映神经退行性疾病脑微观结构的破坏。
[Abstract]:Objective to evaluate the characteristics of white matter in patients with amnesia mild cognitive impairment (MCI) and Alzheimer's disease (AD) by using diffusion Zhang Liang imaging (DTI). In this paper, the damage characteristics of microstructural integrity of gray matter in patients with aMCI and AD were evaluated by using the mean diffusivity (MDM) in DTI, and the transformation law was judged. Methods from January 2014 to December 2016, 30 patients with aMCI and 30 patients with AD in the Gulou Hospital affiliated to Nanjing University Medical College were analyzed retrospectively. The MD values of the whole brain were measured in 30 patients with AD and 30 normal controls. The average diffusivity network of gray water molecules was constructed, the characteristics of small-world networks were calculated, and the correlation analysis was carried out with the scores of neuropsychology. Results compared with CN group and AD group, the average diffusivity network of gray water molecules showed abnormal small-world characteristics, that is, higher aggregation degree and longer path length, which reflected the damage of gray matter microstructure. The average network connectivity of aMCI patients was lower than that of CN group, but higher than that of AD group (P 0.05). There was a negative correlation between the gray matter MD and the Montreal Cognitive Assessment scale (Montreal Cognitive Assessment scale) in the 11 parietal areas including bilateral hippocampus and limbic system (P 0.05). Conclusion the characteristics of water molecular diffusion in the gray matter of aMCI are helpful to discover the preAD patients and reflect the destruction of brain microstructure in neurodegenerative diseases.
【作者单位】：南京市栖霞区妇幼保健院放射科;南京大学医学院附属鼓楼医院医学影像科;
【基金】：南京市医学科技发展项目(YKK15065)
【分类号】：R445.2;R749.1

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