广州市小学生携带甲氧西林耐药与多重耐药金葡菌的耐药性分析

发布时间：2018-05-08 13:14

本文选题：葡萄球菌 + 人　；参考：《中华疾病控制杂志》2017年09期

【摘要】：目的掌握小学生金黄色葡萄球菌(金葡菌)的携带率,并探究菌株的抗生素耐药性。方法对广州市部分在校健康小学生进行鼻拭子采样,对分离的金葡菌进行抗生素药敏试验。结果 1 012名小学生中金葡菌的携带率为40.1%,耐甲氧西林金葡菌的携带率为1.2%,多重耐药金葡菌的携带率为4.0%。金葡菌主要对青霉素、红霉素和克林霉素耐药;多重耐药金葡菌的主要耐药谱为同时对红霉素、克林霉素及四环素耐药和同时对红霉素、克林霉素及头孢西丁耐药。多因子降维法结果显示多重耐药金葡菌对头孢西丁、四环素和氯霉素同时耐药的比例是非多重耐药金葡菌的104.39倍。结论广州市健康小学生金葡菌的携带率较高,呈现出多重耐药状态,为指导社区儿童合理使用抗生素提供数据支持。
[Abstract]:Objective to study the antibiotic resistance of Staphylococcus aureus (Staphylococcus aureus) in primary school students. Methods nasal swabs were collected from some healthy pupils in Guangzhou and antibiotic susceptibility tests were performed on isolated Staphylococcus aureus. Results the carrying rate of Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and multidrug resistant Staphylococcus aureus were 40.1, 1.2 and 4.0 respectively. Staphylococcus aureus was mainly resistant to penicillin, erythromycin and clindamycin, and multidrug resistant Staphylococcus aureus was resistant to erythromycin, clindamycin and tetracycline, as well as erythromycin, clindamycin and cefoxitin. The results of multifactorial dimensionality reduction showed that the proportion of multidrug resistant Staphylococcus aureus to cefoxitin, tetracycline and chloramphenicol was 104.39 times higher than that of non-multidrug resistant Staphylococcus aureus. Conclusion the carrying rate of Staphylococcus aureus among healthy primary school students in Guangzhou is high, showing multidrug resistance, which provides data support for instructing children in community to use antibiotics rationally.
【作者单位】：广东药科大学公共卫生学院;
【基金】：国家自然科学基金(81602901) 广东省科技计划项目(2014A020212306) 广东药学院大学生创新创业培育项目(2015年)
【分类号】：R446.5

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