脑脊液SIL-2R、NSE与血清炎性因子水平在中枢神经系统感染中的意义

发布时间：2018-05-12 20:52

本文选题：中枢神经系统感染 + 脑脊液　；参考：《中华医院感染学杂志》2017年13期

【摘要】：目的分析中枢神经系统感染患者脑脊液可溶性白介素2受体(SIL-2R)、神经元特异性烯醇化酶(NSE)、血清炎性因子的表达水平,探讨脑脊液和血清学检查结果对于中枢神经系统感染诊断的意义。方法选取医院诊治的117例中枢神经系统感染患者作为感染组,根据感染类型分成病毒感染亚组(病毒亚组)39例、化脓性感染亚组(化脓亚组)36例及结核感染亚组(结核亚组)42例,同时选取同期非感染患者35例作为对照组,对比分析各组脑脊液SIL-2R、NSE以及血清炎性因子表达量的差异性。结果感染组脑脊液SIL-2R、NSE、血清PCT、WBC、CRP显著高于对照组,差异有统计学意义(P0.05);结核亚组脑脊液SIL-2R和NSE显著高于其他亚组(P0.05),化脓亚组血清PCT、WBC、CRP显著高于其他亚组,差异有统计学意义(P0.05)。结论中枢神经系统感染患者脑脊液SIL-2R和NSE、血液炎性因子表达多存在明显异常,脑脊液细胞因子与血清炎性因子检测结果能够为中枢神经系统感染诊断与分型提供可靠依据。
[Abstract]:Objective to analyze the expression of soluble interleukin-2 receptor (SIL-2RN), neuron-specific enolase (NSEE), and serum inflammatory factors in cerebrospinal fluid (CSF) patients with central nervous system infection (CNS). To explore the significance of cerebrospinal fluid (CSF) and serological examination in the diagnosis of central nervous system infection (CNS). Methods 117 patients with central nervous system infection were selected as infection group. According to the type of infection, they were divided into virus infection subgroup (virus subgroup, 39 cases), 36 cases of suppurative infection subgroup (purulent subgroup) and 42 cases of tuberculosis infection subgroup (tuberculosis subgroup) were selected as control group. The differences of SIL-2RNSE and serum inflammatory factor expression in cerebrospinal fluid (CSF) were compared and analyzed. Results the levels of SIL-2R and NSE in cerebrospinal fluid of infected group were significantly higher than those in control group (P 0.05), and the levels of SIL-2R and NSE in CSF of tuberculosis subgroup were significantly higher than those in other subgroups (P 0.05). Conclusion the expression of SIL-2R and NSE in cerebrospinal fluid of patients with CNS infection is obviously abnormal. The results of CSF cytokines and serum inflammatory factors can provide reliable basis for the diagnosis and classification of CNS infection.
【作者单位】：海南省人民医院神经外科;
【基金】：海南省自然科学基金资助项目(813210)
【分类号】：R446.14;R742.9

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