儿科重症监护病房患儿血培养病原菌分布及其耐药性

发布时间：2018-05-19 07:25

本文选题：儿科重症监护病房 + 血培养　；参考：《中国感染控制杂志》2017年01期

【摘要】：目的了解儿科重症监护病房(PICU)患儿血培养分离病原菌及其耐药性,为重症患儿血流感染的经验性治疗提供参考依据。方法对该院2011—2015年PICU患儿血培养标本分离的病原菌进行鉴定及药敏分析。结果 3 215份血标本分离病原菌180株,阳性率为5.60%,其中革兰阳性菌153株(85.00%),革兰阴性菌27株(15.00%)。排名前5位的病原菌依次为表皮葡萄球菌、人葡萄球菌、溶血葡萄球菌、大肠埃希菌及金黄色葡萄球菌,分别占26.67%、25.00%、11.66%、5.55%和3.89%。葡萄球菌属细菌对利奈唑胺、万古霉素及奎奴普丁/达福普汀耐药率均为0;耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)、耐甲氧西林金黄色葡萄球菌(MRSA)检出率分别为70.18%、42.86%;大肠埃希菌仅对氨苄西林、头孢唑林、头孢曲松、庆大霉素及复方磺胺甲口恶唑耐药率较高(50.00%~80.00%)。结论 PICU患儿血培养病原菌以凝固酶阴性葡萄球菌(CNS)和大肠埃希菌为主,不同种类CNS的耐药率存在一定差异。
[Abstract]:Objective to investigate the isolation of pathogenic bacteria and their drug resistance in blood culture of children in pediatric intensive care unit (PICU), and to provide reference for empirical treatment of severe blood flow infection in children. Methods the pathogenic bacteria isolated from blood culture specimens of children with PICU from 2011 to 2015 in our hospital were identified and drug sensitivity was analyzed. Results 180 strains of pathogenic bacteria were isolated from 3 215 blood samples, the positive rate was 5.60%, among them 153 strains of Gram-positive bacteria were found to be 85.000.27 strains of Gram-negative bacteria were found to be in the range of 15.00%. The top 5 pathogens were Staphylococcus epidermidis, Staphylococcus hominis, Staphylococcus haemolyticus, Escherichia coli and Staphylococcus aureus, which accounted for 26.67%, 25.00% and 11.66%, 5.55% and 3.89%, respectively. Staphylococcus is a bacterium of the genus paranezolamide, The resistance rates of vancomycin and quinuptin / dafopudine were 0, the positive rates of methicillin-resistant coagulase-negative staphylococci and methicillin-resistant staphylococcus aureus were 70.1818 and 42.86, respectively, and that of Escherichia coli were ampicillin, cefazolin, ceftriaxone, and ceftriaxone, respectively. The resistance rate of gentamicin and sulfamethoxazole was higher than that of compound sulfamethoxazole. Conclusion Coagulase negative staphylococci and Escherichia coli are the main pathogens in blood culture of children with PICU, and the drug resistance rates of different CNS are different.
【作者单位】：南京医科大学附属无锡市人民医院;
【基金】：国家自然科学基金(81400054) 无锡市卫生局妇幼保健项目(FYKY201405)
【分类号】：R446.5

【相似文献】