不同病原体感染血清降钙素元水平的比较

发布时间：2018-05-22 09:19

本文选题：降钙素原 + 血培养　；参考：《浙江大学》2017年硕士论文

【摘要】：目的:探讨血清降钙素原水平对区分不同病原所致感染的价值,是否能指导临床抗生素的使用。方法:通过对共1049例血培养阳性标本及其对应的降钙素原水平进行统计,分析细菌与真菌感染时,降钙素原水平差异;革兰氏阴性菌与革兰氏阳性菌感染时,降钙素原水平差异;胞内菌与胞外菌感染时,降钙素原水平差距;不同种细菌感染时,降钙素原水平分析。结果:血培养检出细菌和真菌病例血清降钙素原水平比较,细菌组降钙素原水平为(15.174±26.616)ng/mL,而真菌组降钙素原水平为(8.126±18.265)ng/mL。P值=0.0070.05。细菌组降钙素原水平明显高于真菌组降钙素原水平,且P值小于0.05,具有统计学意义。革兰氏阳性菌与革兰氏阴性菌病例血清降钙素原水平比较,革兰氏阴性菌组降钙素原水平为(18.792±29.196)ng/mL,而革兰氏阳性菌组降钙素原水平为(8.774±13.990)ng/mL。P值0.01。革兰氏阴性菌降钙素原水平显著高于革兰氏阳性菌降钙素原水平,且P值0.01,具有统计学意义。胞内菌与胞外菌病例血清降钙素原水平比较,胞内菌降钙素原水平为(5.273±13.990)ng/mL,胞外菌降钙素原水平为(15.451±26.833)ng/mL,P=0.0650.05。根据胞内菌及胞外菌统计结果显示,胞外菌降钙素原水平显著高于胞内菌降钙素原水平,但是P值0.05,此结果无统计学意义。结论:降钙素原水平差异,可能能区分不同病原菌血流感染。
[Abstract]:Objective: to investigate the value of serum procalcitonin level in differentiating infection caused by different pathogens and whether it can guide the use of clinical antibiotics. Methods: a total of 1049 blood culture positive specimens and their corresponding procalcitonin levels were analyzed in order to analyze the difference of procalcitonin level between bacteria and fungi, and between Gram-negative bacteria and Gram-positive bacteria. The difference of procalcitonin level between intracellular and extracellular bacteria, and the analysis of procalcitonin level with different bacterial infection. Results: the serum procalcitonin level was 15.174 卤26.616 ng / mL in bacterial group and 8.126 卤18.265)ng/mL.P in fungi group, respectively. The level of procalcitonin in bacterial group was significantly higher than that in fungal group, and the P value was less than 0.05, which was statistically significant. The serum procalcitonin level of Gram-positive bacteria and Gram-negative bacteria was 18.792 卤29.196 ng / mL, while that of Gram-positive bacteria was 8.774 卤13.990)ng/mL.P 0.01. The level of procalcitonin in Gram-negative bacteria was significantly higher than that in Gram-positive bacteria (P = 0.01). The serum procalcitonin level was 5.273 卤13.990 ng / mL in intracellular bacteria and 15.451 卤26.833 ng / mL in extracellular bacteria. According to the statistic results of intracellular bacteria and extracellular bacteria, the level of procalcitonin in extracellular bacteria was significantly higher than that in intracellular bacteria, but there was no significant difference between them (P = 0.05). Conclusion: the difference of procalcitonin level may distinguish the blood stream infection of different pathogens.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R446.5

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