骨化三醇联合羟苯磺酸钙对糖尿病肾病维持腹膜透析患者微炎症、营养状况和生活质量的影响

发布时间：2018-05-26 08:12

本文选题：骨化三醇 + 羟苯磺酸钙　；参考：《现代中西医结合杂志》2017年11期

【摘要】：目的探讨骨化三醇联合羟苯磺酸钙对糖尿病肾病维持腹膜透析患者微炎症及营养状况和生活质量的影响。方法将98例糖尿病肾病行腹膜透析患者随机分为对照组和观察组各49例,对照组给予羟苯磺酸钙口服,观察组在对照组基础上加服骨化三醇,2组均治疗6个月。比较2组治疗前后肾功能、微炎症相关指标的变化,并对患者营养状况及生活质量(SF-36)进行评价。结果治疗后2组血尿素氮(BUN)、血肌酐(SCr)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)水平均较治疗前明显降低(P均0.05),尿素清除分数(Kt/V)均较治疗前明显升高(P均0.05),且观察组BUN、hs-CRP、IL-6、TNF-α、MDA水平均明显低于对照组(P均0.05);治疗后2组血清白蛋白(ALB)、前白蛋白(PA)、血红蛋白(Hb)均明显升高(P均0.05),改良主观综合性营养评估(SGA)评分均明显降低(P均0.05),且组间比较差异均有统计学意义(P均0.05);治疗后2组SF-36评分均显著高于治疗前(P均0.05),且观察组各项评分均显著高于对照组(P均0.05)。结论骨化三醇联合羟苯磺酸钙治疗可改善糖尿病肾病腹膜透析患者微炎症、氧化应激及营养状态,提高患者生活质量。
[Abstract]:Objective to investigate the effects of calcitriol combined with calcium dobesilate on microinflammation, nutritional status and quality of life (QOL) in patients with diabetic nephropathy (DN) maintenance peritoneal dialysis. Methods 98 patients with diabetic nephropathy undergoing peritoneal dialysis were randomly divided into control group (n = 49) and observation group (n = 49). Calcium dobesilate was administered orally in control group. The changes of renal function and microinflammation were compared before and after treatment, and the nutritional status and quality of life (QOL) were evaluated. Results after treatment, the levels of bun, creatinine, hs-CRPN, IL-6, TNF- 伪 TNF- 伪, malondialdehyde (MDA) in the two groups were significantly lower than those before treatment, and the urea clearance fraction (Kt / V) was significantly higher than that before treatment. The levels of MDA in the observation group were significantly lower than those in the control group (P < 0.05), and the levels of serum albumin (Alb), prealbumin (PAA) and hemoglobin (HB) in the two groups were significantly increased after treatment, and the scores of improved subjective comprehensive nutrition assessment (SGAs) were significantly lower than those in the control group (P < 0.05). The level of MDA in the observation group was significantly lower than that in the control group (P < 0.05), and the levels of serum albumin (Alb), prealbumin (PAA) and hemoglobin (HB) in both groups were significantly higher than those in control group. After treatment, the SF-36 scores in the two groups were significantly higher than those in the control group (P < 0.05), and the scores in the observation group were significantly higher than those in the control group (P < 0.05). Conclusion the combination of calcitriol and calcium dobesilate can improve the microinflammation, oxidative stress and nutritional status of patients with diabetic nephropathy peritoneal dialysis, and improve the quality of life of the patients.
【作者单位】：河北北方学院附属第一医院;
【基金】：张家口市科技局项目(1521089D)
【分类号】：R587.2;R692.5

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