原发性失眠患者基于静息态功能磁共振的脑岛功能连接异常区

发布时间：2018-05-28 21:46

本文选题：功能链接静息态磁共振原发性失眠 + 　；参考：《中山大学学报(医学科学版)》2017年04期

【摘要】：【目的】观察静息状态下原发性失眠患者(PI)脑岛功能连接异常。【方法】收集60例PI患者及60例年龄、性别、受教育程度均匹配的健康对照组,采集被试者静息态功能磁共振数据,结合功能连接(FC)分析方法,选取双侧脑岛为感兴趣区域,经双样本t检验,得出全脑范围内两组间脑岛功能连接存在差异的脑区。【结果】与正常对照组相比,PI组双侧脑岛存在多个脑区的功能连接异常,其中与左侧脑岛FC值升高的区域有左侧扣带中回,右侧内侧额上回,右侧顶下缘角回,FC减低的区域有左侧中央前回,右侧梭状回(P0.05);与右侧脑岛FC值升高的区域有右侧扣带中回,右侧梭状回,右侧额中回,FC值减低的区域有右侧中央前回,右侧颞中回(P0.05)。【结论】PI患者双侧脑岛与脑内多个脑区存在异常的功能连接。本研究从功能整合的角度为理解原发性失眠的发生提供了影像证据。
[Abstract]:[objective] to observe the abnormal functional connections of PII in patients with primary insomnia at rest. [methods] 60 patients with Pi and 60 healthy controls with matched age, sex and education were collected. The resting functional magnetic resonance (fMRI) data of the subjects were collected, and the bilateral cerebral islands were selected as the region of interest. The results showed that the functional connections of diencephalic islands were different between the two groups in the whole brain. [results] compared with the normal control group, there were multiple functional connections in the bilateral cerebral islands in the Pi group. There were middle cingulate gyrus in left cerebral island, middle cingulate gyrus in right medial superior frontal gyrus, left precentral gyrus in right inferior parietal angle gyrus, P0.05 in right fusiform gyrus, and right cingulate middle gyrus in those with increased FC value in right cerebral island. In the right fusiform gyrus, the right middle frontal gyrus decreased the FC value in the right precentral gyrus and the right middle temporal gyrus P0.05. [conclusion] there are abnormal functional connections between the bilateral islands and multiple brain regions in Pi patients. This study provides imaging evidence for understanding the occurrence of primary insomnia from the perspective of functional integration.
【作者单位】：揭阳市慈云医院;广东省第二人民医院;
【基金】：广东省自然科学基金(2014A030313673)
【分类号】：R740

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