乌司他丁注射剂联合血液净化术治疗重症感染性休克患者的临床研究

发布时间：2018-05-30 04:26

本文选题：乌司他丁 + 血液净化术　；参考：《中国临床药理学杂志》2017年21期

【摘要】：目的观察乌司他丁注射剂联合血液净化术对重症感染性患者的炎症介质及氧合指数的影响。方法将100例重症感染性休克患者随机分为对照组50例和试验组50例。对照组进行常规治疗;试验组在对照组的基础上加用乌司他丁20万U+0.9%NaCl 20 mL+血液净化术治疗24 h,治疗持续3 d。比较2组患者的临床疗效、肿瘤坏死因子-α、白细胞介素-8、白细胞介素-6、氧合指数(PaO_2/FiO_2)及药物不良反应的发生情况。结果治疗后,试验组患者总有效率为90.00%(45例/50例),对照组为52.00%(26例/50例),差异有统计学意义(P0.05)。治疗后,试验组的肿瘤坏死因子-α、白细胞介素-8、白细胞介素-6分别为(8.39±3.14),(4.21±1.14),(4.95±1.77)μg·L~(-1),对照组分别为(17.28±2.91),(9.07±1.04),(10.99±1.32)μg·L~(-1),差异均有统计学意义(均P0.05)。治疗后1,12,24,72 h,试验组氧合指数分别为141.21±16.92,187.82±21.51,203.12±26.30,284.21±45.12,对照组分别为135.31±19.23,149.30±20.60,178.72±29.21,199.60±40.52,差异均有统计学意义(均P0.05)。2组患者治疗期间均未发生药物不良反应。结论乌司他丁联合血液净化术对重症感染性休克患者的疗效更加显著,明显降低炎症介质,改善患者的氧合指数。
[Abstract]:Objective to observe the effect of ulinastatin injection combined with blood purification on inflammatory mediators and oxygenation index in severe infectious patients. Methods 100 patients with severe septic shock were randomly divided into control group (n = 50) and experimental group (n = 50). The experimental group was treated with ulinastatin 200000 U 0.9%NaCl 20 mL blood purification for 24 h for 3 days. The clinical efficacy, tumor necrosis factor- 伪, interleukin-8, interleukin-6, Pao _ 2 / FiO _ 2) and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rate of 45 cases / 50 cases in the trial group was 90.00,50 cases in the control group, 52.00 cases / 50 cases in the control group. The difference was statistically significant (P 0.05). After treatment, the levels of tumor necrosis factor- 伪, interleukin-8 and interleukin-6 were 8.39 卤3.14, 4.21 卤1.14, 4.95 卤1.77) 渭 g / L in the experimental group and 9.07 卤1.0499 卤1.32 渭 g / L in the control group, respectively (P 0.05). The oxygenation index of the experimental group was 141.21 卤16.92187.82 卤21.51203.12 卤26.30284.21 卤45.12h after treatment, and that of the control group was 135.31 卤19.23149.30 卤20.60178.72 卤29.21199.60 卤40.52.The difference was statistically significant (P 0.05). Conclusion Ulinastatin combined with blood purification is more effective in the treatment of severe septic shock patients. It can significantly reduce the inflammatory mediators and improve the oxygenation index of patients with severe septic shock.
【作者单位】：海南省人民医院重症医学科;
【基金】：海南省自然科学基金资助项目(814321)
【分类号】：R459.7

【相似文献】