奇异变形菌分布与耐药性分析

发布时间：2018-06-08 23:03

本文选题：奇异变形菌 + 耐药性　；参考：《中华医院感染学杂志》2017年12期

【摘要】：目的了解医院奇异变形菌感染分布情况及耐药变迁,为临床合理使用抗菌药物提供参考。方法对2005年1月-2015年12月医院分离的奇异变形菌的分布及耐药情况进行统计分析。结果 11年非重复分离奇异变形菌共1442株,占所有住院患者非重复分离肠杆菌科细菌的6.87%,且分离率波动不大;主要分离于痰、尿、分泌物及血标本等,分别占32.11%、34.81%、14.42%和1.25%;药敏结果显示奇异变形菌对哌拉西林、哌拉西林/他唑巴坦、头孢替坦、头孢他啶、头孢吡肟、氨曲南、亚胺培南、美洛培南、阿米卡星及头孢哌酮/舒巴坦等的耐药率较低,分别为9.42%、1.09%、1.65%、6.42%、7.54%、3.96%、1.43%、0.14%、5.83%和4.06%,可作为经验首选药;氨苄西林、头孢唑林和磺胺甲VA唑/甲氧苄啶耐药率较高,分别为52.56%、58.37%和51.67%,需加强临床使用规范;从呼吸道分离的奇异变形菌对头孢替坦、头孢他啶及阿米卡星的耐药率高于从尿液分离的奇异变形菌,而对环丙沙星的耐药率低于从尿液中分离的奇异变形菌,均具有统计学差异。结论加强医院感染细菌学的检测和动态分析,对制定有效感染控制措施及杜绝感染暴发具有重要意义。
[Abstract]:Objective to investigate the distribution of Proteus mirabilis infection and the change of drug resistance in hospital, and to provide reference for rational use of antimicrobial agents in clinic. Methods the distribution and drug resistance of Proteus mirabilis isolated from hospitals from January 2005 to December 2015 were analyzed statistically. Results A total of 1442 strains of non-repeated isolates of Proteus mirabilis were isolated in 11 years, accounting for 6.87% of all non-repeated isolates of Enterobacteriaceae, and the isolation rate was not significant. The isolates were mainly isolated from sputum, urine, secretions and blood samples. 14.42% and 1.25%, respectively, of 32.110.81% and 1.25%, respectively. The results of antimicrobial susceptibility showed that Proteus mirabilis was resistant to piperacillin, piperacillin / tazobactam, ceftitan, ceftazidime, cefepime, aztreonam, imipenem, and meropenem. The drug resistance rates of amikacin and cefoperazone / sulbactam were lower, 9.42 and 1.09, respectively, and 1.65 and 6.42, respectively. The drug resistance rate of ampicillin, cefazolin and sulfamethoxazole / trimethoprim was higher than that of ampicillin, cefazolin and sulfamethoxazole / trimethoprim, and the drug resistance rate of amicacin and cefazolin was higher than that of ampicillin, cefazolin and sulfamethoxazole / trimethoprim. 58.37% and 51.67%, respectively, of 52.56% and 51.67%, respectively. The resistance rate of Proteus mirabilis isolated from respiratory tract to ceftitan, ceftazidime and amikacin was higher than that of urine. The resistance to ciprofloxacin was significantly lower than that of Proteus mirabilis isolated from urine. Conclusion strengthening the detection and dynamic analysis of nosocomial infection bacteriology is of great significance in making effective infection control measures and preventing infection outbreak.
【作者单位】：天津市第一中心医院检验科;
【基金】：天津市卫生局面上基金资助项目(2015KY10)
【分类号】：R446.5

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