合肥市无偿献血人群HIV筛查和确证结果及人口特征分析

发布时间：2018-06-13 01:49

本文选题：合肥市 + 献血者　；参考：《中国输血杂志》2017年05期

【摘要】：目的了解合肥市无偿献血者中人类免疫缺陷病毒(HIV)流行情况和HIV感染者的人口特征,指导招募低危献血者,进而指导制定合适的血液筛查策略,降低经血传播HIV的风险。方法安徽省血液中心检验科采用1种国产三代酶联免疫试验(ELISA)试剂和1种进口四代ELISA试剂,以及核酸检测(NAT)试剂进行HIV筛查,筛查反应性标本送确证实验室进行确证。统计安徽省血液中心2014年1月-2015年12月HIV筛查呈反应性的献血者确证结果进行回顾性分析。结果 2年时间内ELISA试剂筛查了215 015份标本,筛查呈反应性并送确证实验室标本554份,经确证阳性41份(均为ELISA双试剂反应性),确证阳性率为7.4%:其中男性38例,女性3例;小于30岁的有24例,占58.5%;首次献血有32位,占78%。2年时间内,NAT筛查了203 999例标本,ELISA-/NAT+9例,经鉴定均为阴性。结论近年来合肥市无偿献血者中HIV感染者较高,主要集中在30岁以下的首次男性献血者,应做好这部分献血者的咨询工作,降低输血传播HIV的风险。
[Abstract]:Objective to investigate the prevalence of human immunodeficiency virus (HIV) and HIV infection among unpaid blood donors in Hefei, and to guide the recruitment of low risk blood donors, and to establish appropriate blood screening strategies to reduce the risk of transmission of HIV through blood. Methods the laboratory of Anhui Blood Center used one kind of domestic three generation Elisa reagent, one kind of imported four generation Elisa reagent, and one kind of nucleic acid test (NATA) reagent for HIV screening, and the screening reactive samples were sent to the confirmation laboratory for confirmation. From January 2014 to December 2015, the confirmed results of HIV screening in Anhui Blood Center were retrospectively analyzed. Results within 2 years, 215,015 samples were screened by Elisa reagent, 554 samples were screened and confirmed in laboratory. 41 samples were confirmed positive by Elisa. The positive rate was 7.4%: 38 males and 3 females; 24 cases (58.5%) were younger than 30 years old, 32 cases (78.2 years) were first donated blood samples were screened for ELISA-rnat in 78,999 cases, all of them were identified as negative. Conclusion in recent years, the HIV infection rate among the unpaid blood donors in Hefei is relatively high, mainly concentrated in the first time male blood donors under 30 years old. It is necessary to do a good job in counseling this part of blood donors to reduce the risk of blood transfusion and transmission of HIV.
【作者单位】：安徽医科大学第二附属医院检验科;安徽省血液中心;中国医学科学院北京协和医学院输血研究所;
【基金】：国家自然科学基金资助项目(81171662)
【分类号】：R446.6;R512.91

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