Mur血型抗原抗体调查及应用研究

发布时间：2018-06-16 20:58

  本文选题：Mur血型 + 抗-Mur　； 参考：《中国输血杂志》2017年06期

【摘要】：目的了解广东地区人群抗-Mur发生频率、性质和来源以及Mur抗原的分布;建立献血者Mur稀有血型库服务于临床用血。方法以微量板的盐水法和聚凝胺法对广东省中山、深圳、江门、东莞、惠州市34 419名献血者做抗-Mur筛查,用抗-Mur做红细胞Mur抗原筛查,部分标本采用固相免疫吸附试验(SPIA)筛查。结果本组筛查对象共检出抗-Mur 48例,占0.14%(48/34 419),其中IgM占79.2%(38/48),IgM+IgG占16.7%(8/48),IgG占4.2%(2/48);献血者抗-Mur频率比较,无显著性差异(P0.05);中山患者抗-Mur频率为0.17%(5/3010),与献血者比较无明显差异(P0.05);中山地区,Mur抗原在献血者、患者中的发生率分别为7.31%(128/1 752)vs 7.14%(80/1 120),P0.05,献血者男性和女性中分别为7.7%(72/931)vs 6.5%(33/504),P0.05;本组Mur阳性者均为汉族,其中广东省籍贯占66.7%(70/105);建立了中山地区献血者Mur稀有血型库;SPIA技术从2 541份血浆标本中检出4例抗-Mur。结论 SPIA可以检出37℃活性有较高临床意义的抗-Mur,广东地区献血人群Mur血型抗体、抗原发生频率均明显高于Rh D血型抗体、抗原发生频率,不规则抗体检测应增加Mur阳性筛选红细胞,供受血者均应检测Mur血型是否相合,以进一步提高输血免疫安全性。
[Abstract]:Objective to investigate the frequency, nature and origin of anti--Mur and the distribution of Mur antigen in Guangdong population, and to establish Mur rare blood group bank for clinical use. Methods 34,419 blood donors from Zhongshan, Shenzhen, Jiangmen, Dongguan and Huizhou were screened for anti--Mur and anti--Mur for erythrocyte Mur antigen screening, and some samples were screened by solid phase immunosorbent assay (SPIA). Results A total of 48 cases of anti--Mur were detected in this group, accounting for 0.14% of 34 419 cases, in which IgM accounted for 79.2% / 48% IgM IgG accounted for 16.710% and 8 / 48% of IgG accounted for 4.2% of 48%, and the frequency of anti--Mur in blood donors was compared. There was no significant difference (P 0.05), the frequency of anti--Mur in Zhongshan patients was 0.17 / 3 010%, and there was no significant difference between the blood donors and the blood donors, and the Mur antigen was in the blood donors in Zhongshan area, and there was no significant difference between the blood donors and the blood donors. The incidence of Mur in the patients was 7.38 / 1 752)vs 7.14 and 80 / 1 120 / respectively (P0.05). In the male and female blood donors, 7.7%(72/931)vs 6.5 / 504 / P0.05, respectively. Among them, Guangdong Province accounted for 66.7% of 70 / 105% of the blood group, and 4 cases of anti-Murr were detected from 2 541 plasma samples by using SPIA technique of Mur rare blood group bank of blood donors in Zhongshan area. Conclusion SPIA can detect anti-Murr with high clinical significance at 37 鈩，

本文编号：2028086