氧化应激相关指标在慢性肾脏病诊断中的价值

发布时间：2018-06-20 04:30

  本文选题：慢性肾脏病 + 氧化应激　； 参考：《预防医学》2017年04期

【摘要】：目的探讨氧化应激相关指标在慢性肾脏病(CKD)早期诊断和病情评估中的价值。方法选择2014年8月—2015年12月在浙江大学医学院附属第二医院肾脏内科住院治疗的CKD患者220例,选择2015年12月在该医院体检正常的100人作为对照。分别测定两组血清肌酐(Cr)、尿酸(UA)、γ-谷氨酰转肽酶(GGT)、同型半胱氨酸(HCY)水平,并比较两组差异。根据Cr水平,估算肾小球滤过率(GFR),划定CKD临床分期。采用受试者工作特征(ROC)曲线比较CKD I、CKD II组患者和对照组UA、GGT、HCY单项检测及3项联合检测的准确性。结果 CKD组血清Cr、UA、GGT、HCY水平均高于对照组(P0.05),在CKD组与对照组的鉴别诊断研究中,UA、GGT、HCY单项和3项联合检测的ROC曲线下面积(AUC)值分别为0.823、0.585、0.850和0.924,单项临床诊断价值均低于3项联合(P0.05)。在CKDⅠ组与对照组的鉴别诊断研究中,UA、GGT、HCY单项和3项联合检测的AUC值分别为0.711、0.594、0.716和0.807,单项临床诊断价值均低于3项联合(P0.05)。在CKDⅠ组与Ⅱ组的鉴别诊断研究中,3项联合检测的AUC值为0.834,与HCY单项检测的AUC值0.828相比,差异无统计学意义(P0.05)。结论 UA、GGT、HCY 3项指标的联合检测在CKD早期临床诊断中具有较高的应用价值,在CKD晚期单独检测HCY与3项联合检测的诊断价值相近。
[Abstract]:Objective to investigate the value of oxidative stress related indexes in early diagnosis and evaluation of chronic kidney disease (CKD). Methods 220 patients with CKD were selected from August 2014 to December 2015 in the second affiliated Hospital of Zhejiang University Medical College, and 100 patients who had normal physical examination in the hospital were selected as control. Serum creatinine (Cr), uric acid (UAA), 纬 -glutamyl transpeptidase (GGTN) and homocysteine (HCY) were measured in the two groups, and the differences between the two groups were compared. According to the level of Cr, the glomerular filtration rate (GFR) was estimated and the clinical stage of CKD was determined. The accuracy of single test and three items of combined detection of UAG GTN HCY in CKD Igna CKD II group and control group were compared by using the operating characteristics of the subjects. Results the level of GGTHCY in serum of CKD group was higher than that of control group (P 0.05). In the differential diagnosis of CKD group and control group, the area under ROC curve was 0.823 卤0.5850.850 and 0.924, respectively, and the value of single clinical diagnosis was lower than that of P0.05. In the study of differential diagnosis between CKD 鈪，

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