肝组织弥散度成像在慢性肝损伤诊断中的临床研究

发布时间：2018-06-28 00:52

本文选题：肝脏 + 纤维化　；参考：《现代生物医学进展》2017年05期

【摘要】：目的:探讨Strain Histogram组织弥散度成像技术在慢性肝损伤程度无创诊断中的临床价值。方法:应用Strain Histogram组织弥散度成像技术定量检测180例慢性肝炎(病毒性肝炎105例,非病毒性肝炎75例)患者肝脏弹性特征值,对照病理,分析肝脏弹性特征值与肝纤维化及肝脏炎症程度的相关性。结果:180例慢性肝炎患者LF指数用于判断轻度与中重度纤维化的诊断界值为2.785,LF指数越大,纤维化程度越重,灵敏度76.6%,特异度48.9%;LF指数用于判断轻度与中重度炎症的诊断界值为2.925,LF指数越大,炎症程度越重,灵敏度73.2%,特异度56.8%。105例病毒性肝炎患者LF指数用于判断轻度与中重度纤维化的诊断界值为2.975,LF指数越大,纤维化程度越重,灵敏度69.2%,特异度67.1%;LF指数用于判断轻度与中重度炎症的诊断界值为2.915,LF指数越大,炎症程度越重,灵敏度80.0%,特异度57.8%。75例非病毒性肝炎患者LF指数与肝纤维化和炎症程度不具有相关性。结论:LF指数可以反映肝脏纤维化及炎症程度,诊断灵敏度高,LF指数越大,肝纤维化及炎症程度越重。
[Abstract]:Objective: to evaluate the clinical value of histogram tissue diffusion imaging in noninvasive diagnosis of chronic liver injury. Methods: the characteristic values of liver elasticity in 180 patients with chronic hepatitis (105 patients with viral hepatitis and 75 patients with non-viral hepatitis) were detected by histogram tissue diffusion imaging. To analyze the correlation between the characteristic value of liver elasticity and the degree of liver fibrosis and inflammation. Results the LF index of 180 patients with chronic hepatitis was used to determine the diagnostic threshold of mild and moderate fibrosis. The larger the LF index was, the more the degree of fibrosis was. Sensitivity 76. 6. The specificity of LF index is 48. 9%. The diagnostic threshold of mild and moderate to severe inflammation is 2. 925% LF index is higher, the degree of inflammation is more serious. Sensitivity 73.2%, specificity 56.8%. 105 patients with viral hepatitis, LF index was used to judge mild and moderate fibrosis. The diagnostic threshold value of LF index was 2.975%. The higher the LF index was, the more serious the fibrosis degree was. The sensitivity 69.2%, the specificity 67.1% LF index is used to judge the mild and moderate severe inflammation, the greater the diagnostic threshold value is 2.915% LF index, the more severe the inflammation degree. The sensitivity was 80.0 and the specificity was 57.8%. There was no correlation between LF index and the degree of liver fibrosis and inflammation in 75 patients with non-viral hepatitis. Conclusion the higher the sensitivity of diagnosis, the greater the degree of liver fibrosis and inflammation.
【作者单位】：解放军第三0二医院超声科;
【基金】：解放军302医院创新基金项目(YNKT2012033)
【分类号】：R575;R445.1

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