产超广谱β-内酰胺酶大肠埃希菌与肺炎克雷伯菌2013-2015年耐药谱动态分析

发布时间：2018-07-01 07:51

本文选题：产ESBLs大肠埃希菌 + 肺炎克雷伯菌　；参考：《中华医院感染学杂志》2017年12期

【摘要】：目的分析2013-2015年医院产ESBLs大肠埃希菌和肺炎克雷伯菌耐药性变迁情况,旨在合理制定医院感染抗菌治疗方案。方法选取医院2013年1月-2015年12月诊治的感染性疾病患者标本,分析各类标本中产ESBLs大肠埃希菌和肺炎克雷伯菌检出情况,分析病原菌耐药性,同时对所得数据行统计比较。结果 2013年-2015年产ESBLs大肠埃希菌株检出率依次是7.92%、9.30%、8.77%,肺炎克雷伯菌检出率依次是21.31%、20.57%、20.17%,各年份产ESBLs大肠埃希菌株和肺炎克雷伯菌检出率,无显著性差异;产ESBLs大肠埃希菌对头孢菌素、青霉素类耐药性最高,2014年头孢吡肟耐药率为100.00%,对替加环素、美罗培南、亚胺培南耐药性较低,其中替加环素为0%,且2015年产ESBLs大肠埃希菌对米诺环素、头孢噻肟耐药率显著高于2014年水平(P0.05);2013年-2015年肺炎克雷伯菌对氨苄西林耐药率最高,对哌拉西林、环丙沙星、头孢类药物耐药率不断升高,肺炎克雷伯菌对亚胺培南、美罗培南耐药率低。结论产ESBLs大肠埃希菌及肺炎克雷伯菌均为感染性疾病的主要致病菌,二者对常见抗菌药物均有较高耐药性,且随着年代更替,其耐药谱有一定变迁。
[Abstract]:Objective to analyze the drug resistance changes of ESBLs-producing Escherichia coli and Klebsiella pneumoniae in hospitals from 2013 to 2015 in order to make a rational treatment plan for nosocomial infection. Methods ESBLs-producing Escherichia coli and Klebsiella pneumoniae were detected from patients with infectious diseases from January 2013 to December 2015. Results from 2013 to 2015, the detection rate of ESBLs-producing Escherichia coli and Klebsiella pneumoniae was 7.929.30 and 8.77, respectively, and the positive rate of Klebsiella pneumoniae was 21.31 and 20.57 respectively. There was no significant difference between ESBLs-producing Escherichia coli and Klebsiella pneumoniae in each year, and ESBLs-producing Escherichia coli on cephalosporins. The resistance rate of cefepime in 2014 was 100.00.The resistance to tegacycline, meropenem and imipenem was low, and the resistance of tegacyclin was 0, and ESBLs were produced to minocycline in 2015. The resistance rate of cefotaxime was significantly higher than that of 2014 (P0.05); Klebsiella pneumoniae had the highest resistance rate to ampicillin from 2013 to 2015, and to piperacillin, ciprofloxacin, cephalosporin, and Klebsiella pneumoniae to imipenem. The resistance rate of meropenem was low. Conclusion ESBLs-producing Escherichia coli and Klebsiella pneumoniae are the main pathogens of infectious diseases. Both of them have high resistance to common antimicrobial agents.
【作者单位】：唐山市工人医院急诊内科;唐山市工人医院检验科;唐山市工人医院感染科;
【分类号】：R446.5

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