动态增强磁共振成像定量评估健康志愿者胰腺灌注的可行性

发布时间：2018-07-23 15:15

【摘要】：目的探讨动态增强磁共振成像(DCE-MRI)量化评估胰腺灌注的可行性。方法将68名健康志愿者分为青年组、中年组和老年组。对所有志愿者均行DCE-MRI,将数据传至Research-DCEMRI Tool诊断分析工作站,计算胰腺灌注的定量参数:容积转运常数(Ktrans)、间质-血浆速率常数(Kep)、间质容积(Ve)和血浆容积(Vp)。采用两独立样本t检验和单因素方差分析评估不同性别、年龄组和胰腺部位的灌注参数。结果不同性别志愿者Ktrans、Kep、Ve和Vp差异均无统计学意义(P均0.05);老年组Ve高于青年组和中年组(P=0.036、0.001);胰头区Vp高于胰体部和胰尾部(P=0.011、0.023)。结论 DCE-MRI可无创、较稳定、定量评估胰腺灌注情况。胰腺DCE-MRI定量灌注参数不随性别差异而不同,但随年龄和胰腺部位的不同而有差异。
[Abstract]:Objective to evaluate the feasibility of quantitative assessment of pancreatic perfusion by dynamic enhanced magnetic resonance imaging (DCE-MRI). Methods 68 healthy volunteers were divided into youth group, middle age group and elderly group. All volunteers were given DCE-MRI, and the data were transmitted to the Research-DCEMRI Tool diagnostic and analysis workstation to calculate the quantitative parameters of pancreatic perfusion: volume transport constant, (Ktrans), interstitial constant, plasma rate constant, interstitial volume (Ve) and plasma volume (Vp)., interstitial volume (Ve) and plasma volume (Vp). T test and single factor ANOVA were used to evaluate the perfusion parameters of different sex, age group and pancreas. Results there was no significant difference in Ve and VP between male and female volunteers (P 0.05), but there was no significant difference between the elderly group and the young group and the middle age group (P0.036 0. 001), and the VP in the head of pancreas was higher than that in the body and tail of the pancreas (P 0. 011 0. 023), and that in the head of pancreas was higher than that in the young group and the middle age group (P0. 036 卤0. 001). Conclusion DCE-MRI is noninvasive and stable, and the pancreatic perfusion can be evaluated quantitatively. The quantitative perfusion parameters of pancreatic DCE-MRI were not different with sex, but different with age and location of pancreas.
【作者单位】：第四军医大学西京医院放射科;
【基金】：国家自然科学基金(81220108011)
【分类号】：R445.2

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