2016年安徽省滁州市第一人民医院临床分离菌耐药性监测

发布时间：2018-08-13 13:48

【摘要】：目的了解2016年滁州市第一人民医院常见临床分离菌的分布及耐药情况。方法各类临床分离菌采用MicroScan WalkAway 96 PLUS进行鉴定和药敏试验,采用WHONET5.6软件对数据进行统计分析。结果 2016年共分离病原菌1 441株,其中革兰阳性菌409株,占28.4%;革兰阴性菌1 032株,占71.6%。葡萄球菌中耐甲氧西林金黄色葡萄球菌(MRSA)和凝固酶阴性葡萄球菌(MRCNS)的检出率分别为37.5%和83.0%。葡萄球菌中未见对万古霉素、达托霉素和利奈唑胺耐药的菌株。肠球菌中屎肠球菌对达托霉素、万古霉素和利奈唑胺全敏感,检出1株耐利奈唑胺粪肠球菌,检出率为2.6%。肺炎链球菌主要来源于儿科,对青霉素全敏感。大肠埃希菌、克雷伯菌属(肺炎克雷伯菌和产酸克雷伯菌)和奇异变形杆菌产ESBL的检出率分别为49.1%、24.2%和62.5%,产ESBL株对监测药物的耐药率均高于非产ESBL株。铜绿假单胞菌对亚胺培南和美罗培南的耐药率均为10.4%。不动杆菌属(鲍曼不动杆菌占95.0%)对亚胺培南和美罗培南的耐药率分别为79.0%和78.2%。结论 2016年该医院分离的革兰阴性杆菌耐药情况严重,肺炎克雷伯菌和鲍曼不动杆菌对碳青霉烯类抗菌药物的耐药率呈上升趋势,应引起重视。
[Abstract]:Objective to investigate the distribution and drug resistance of common clinical isolates in the first people's Hospital of Chuzhou City in 2016. Methods all kinds of clinical isolates were identified by MicroScan WalkAway 96 PLUS and drug sensitivity test. The data were statistically analyzed by WHONET5.6 software. Results A total of 1 441 strains of pathogenic bacteria were isolated in 2016, of which 409 were Gram positive bacteria (28. 4%), 1 032 were Gram-negative bacteria (71. 6%). The detectable rates of methicillin-resistant Staphylococcus aureus (MRSA) and coagulase-negative staphylococcus (MRCNS) were 37.5% and 83.0%, respectively. No vancomycin, daptomycin and linazolamide resistant strains were found in Staphylococcus. Enterococcus faecium was completely sensitive to daptomycin, vancomycin and linazolamide. A strain of Enterococcus faecalis resistant to renazolamine was detected, and the detection rate was 2.6%. Streptococcus pneumoniae mainly comes from paediatrics and is completely sensitive to penicillin. The positive rates of ESBL production of Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis were 49.2% and 62.5%, respectively. The drug resistance rate of ESBL producing strains was higher than that of non-producing ESBL strains. The resistance rates of Pseudomonas aeruginosa to imipenem and meropenem were 10.4%. The resistance rates of Acinetobacter (Acinetobacter baumannii) to imipenem and meropenem were 79.0% and 78.2%, respectively. Conclusion the drug resistance of Gram-negative bacilli isolated from the hospital in 2016 is serious. The resistance rate of Klebsiella pneumoniae and Acinetobacter baumannii to carbapenem antibiotics is on the rise and should be paid more attention.
【作者单位】：安徽省滁州市第一人民医院检验科;
【分类号】：R446.5

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