俯卧位通气在新生儿呼吸窘迫综合征中应用效果的Meta分析
发布时间：2018-08-18 19:06
【摘要】：目的系统评价俯卧位通气在新生儿呼吸窘迫综合征中的应用效果。方法计算机检索Pub Med、EMBASE、Cochrane Library、Web of Science、中国生物医学文献数据库、中国学术期刊全文数据库、万方和维普等国内外数据库中有关俯卧位通气应用于新生儿呼吸窘迫综合征的随机对照试验和随机交叉试验。对所得文献依据纳入与排除标准进行筛查,提取资料,评价文献质量,采用Rev Man 5.3软件进行Meta分析。结果最终共纳入10项研究,7项随机对照试验和3项随机交叉试验,包括500例研究对象。Meta分析结果显示,俯卧位通气组的SaO_2[MD=2.41,95%CI(0.87,3.95),P=0.002]、PaO_2[MD=5.20,95%CI(3.04,7.36),P0.001]、PaO_2/FiO_2[MD=24.40,95%CI(8.35,40.44),P=0.003]、气胸发生率[RR=0.10,95%CI(0.01,0.76),P=0.03]、颅内出血发生率[RR=0.41,95%CI(0.20,0.83),P=0.01]和机械通气时间[MD=-23.22,95%CI(-38.30,-8.14),P=0.003]与仰卧位通气组相比,差异具有统计学意义;呼吸机相关性肺炎发生率[RR=0.72,95%CI(0.48,1.09),P=0.12]与仰卧位通气组相比,差异无统计学意义。结论俯卧位通气能够有效改善呼吸窘迫综合征新生儿的SaO_2、PaO_2和PaO_2/FiO_2,缩短机械通气时间,降低气胸和颅内出血的发生风险,而对降低呼吸机相关性肺炎的发生率则无明显作用。由于本研究评价指标间存在异质性,且各评价指标纳入的符合标准的研究也不足。因此,需要更多临床多中心、大样本、高质量的研究进一步评价俯卧位通气应用于新生儿呼吸窘迫综合征的效果。
[Abstract]:Objective to evaluate the effect of prone position ventilation in neonatal respiratory distress syndrome. Methods A computer search was conducted for Pub Medmella Cochrane Library Web of Science, Chinese Biomedical Literature Database and full text Database of Chinese academic Journals. The application of prone position ventilation in the databases of Wanfang and Wiper in neonatal respiratory distress syndrome is a randomized controlled trial and a random cross trial. According to the inclusion and exclusion criteria, the literature was screened, the data was extracted, the quality of the literature was evaluated, and the Meta analysis was carried out with Rev Man 5.3 software. Results A total of 10 randomized controlled trials and 3 randomized crossover trials were included, including 500 subjects. Meta-analysis showed that, 淇崸浣嶉，
本文编号：2190395
[Abstract]:Objective to evaluate the effect of prone position ventilation in neonatal respiratory distress syndrome. Methods A computer search was conducted for Pub Medmella Cochrane Library Web of Science, Chinese Biomedical Literature Database and full text Database of Chinese academic Journals. The application of prone position ventilation in the databases of Wanfang and Wiper in neonatal respiratory distress syndrome is a randomized controlled trial and a random cross trial. According to the inclusion and exclusion criteria, the literature was screened, the data was extracted, the quality of the literature was evaluated, and the Meta analysis was carried out with Rev Man 5.3 software. Results A total of 10 randomized controlled trials and 3 randomized crossover trials were included, including 500 subjects. Meta-analysis showed that, 淇崸浣嶉，
本文编号：2190395
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