不同频率音乐对小鼠空间学习记忆能力的影响

发布时间：2018-09-08 16:18

【摘要】：目的初步探究音乐对成年小鼠学习记忆能力是否产生影响。方法 80只C57小鼠随机分成10组,每组雌雄各半。空白对照组:不给予音乐刺激,高频音乐3组、中频音乐3组、低频音乐3组,分别用高频、中频、低频各3首进行音乐刺激,每天5 h,连续6 d。第7天进行水迷宫测试,期间保持音乐刺激不变,测试指标为潜伏期,经过平台次数和平台象限停留时间。结果音乐组与空白组相比,小鼠逃避潜伏期明显缩短(P0.05),经过平台次数和平台象限停留时间虽有增多,但差异无显著性(P0.05)。各音乐组之间检测指标差异无显著性(P0.05)。结论所选9首音乐能提高成年小鼠学习记忆能力,而不同频率音乐之间产生的影响未发现显著性差异。推测音乐刺激对小鼠的影响与音乐分类的标准、刺激周期长短、刺激时间点选择等因素密切相关。
[Abstract]:Objective to explore the effect of music on learning and memory ability of adult mice. Methods 80 C57 mice were randomly divided into 10 groups with half male and female in each group. Blank control group: no music stimulation, high frequency music group 3, middle frequency music group 3, low frequency music group 3, respectively, with high frequency, middle frequency, low frequency three music stimulation, 5 hours a day for 6 days. On the 7th day, the water maze test was carried out, during which the music stimulation remained unchanged, the test index was the latency, the number of passes through the platform and the stay time of the platform quadrant. Results compared with the blank group, the escape latency of the music group was significantly shorter (P0.05), the number of passes through the platform and the stay time of the platform quadrant were increased, but the difference was not significant (P0.05). There was no significant difference between the music groups (P0.05). Conclusion the selected 9 pieces of music can improve the learning and memory ability of adult mice, but there is no significant difference in the effects of different frequencies of music. It was inferred that the influence of music stimulation on mice was closely related to the criteria of music classification, the duration of stimulation period and the selection of stimulation time points.
【作者单位】：重庆医科大学公共卫生与管理学院;重庆医科大学实验动物中心;
【基金】：重庆市科委社会民生项目(编号:cstc2017shms A0007) 重庆医科大学大学生科学研究与创新实验项目(编号:201663)
【分类号】：R-33;R493

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