线性参照区域模型DCE-MRI在乳腺良、恶性病变诊断效能的研究

发布时间：2018-09-19 08:06

【摘要】：目的探讨线性参照区域模型DCE-MRI对乳腺良、恶性病变的诊断价值。方法回顾性分析经手术病理或其他方式确诊的32例(32个病灶)乳腺癌和30例(30个病灶)良性病变患者;以良性病变组对侧正常腺体作为正常对照组。所有患者均行3.0 T磁共振定量动态增强扫描,分别测量病灶LRRM模型的容量转移常数(K~(trans))、速率常数(K_(ep))及血管外细胞外间隙容积(Ve)。采用单因素方差分析进行多组间比较,组间两两比较采用LSD法;绘制良恶性病变组K~(trans)、K_(ep)值的ROC曲线,并寻找两者诊断乳腺良、恶性病变的最佳界值。结果正常腺体组、良性病变组及恶性病变组的K~(trans)值分别为(0.224±0.136)min~(-1)、(0.539±0.242)min~(-1)、(1.371±0.709)min~(-1);K_(ep)值分别为(0.115±0.052)min~(-1)、(0.313±0.149)min~(-1)、(0.851±0.425)min~(-1),组间两两比较差异均有统计学意义(P0.05);正常腺体组、良性病变组及恶性病变组的Ve值分别为0.186±0.096、0.240±0.175、0.212±0.140;多组间比较无差异(P㧐0.05)。良恶性病变间K~(trans)值及K_(ep)值ROC曲线下面积分别为0.905及0.936;最佳诊断界值分别为0.786 min~(-1)及0.410 min~(-1);诊断的敏感性分别为81.3%及93.8%,特异性分别为80.0%及83.3%。结论 LRRM模型DCE-MRI所测得K~(trans)、K_(ep)值稳定;K~(trans)、K_(ep)值对乳腺良、恶性病变的诊断有着较高的价值。LRRM模型DCE-MRI是一种有效的定量检查方法。
[Abstract]:Objective to evaluate the diagnostic value of linear reference region model (DCE-MRI) in benign and malignant breast lesions. Methods 32 patients with breast cancer (32 lesions) and 30 patients with benign lesions (30 lesions) confirmed by surgical pathology or other methods were retrospectively analyzed. The contralateral normal glands in benign lesions group were used as normal control group. All the patients underwent 3. 0T Mr quantitative dynamic enhanced Mr scanning. The volume transfer constant (K _ (ep) and extracellular space volume (Ve).) of the focus LRRM model were measured, respectively. Single factor variance analysis (ANOVA) was used to carry out the multigroup comparison and the LSD method was used to compare the two groups. The ROC curve of K ~ (trans) K _ (ep) value of benign and malignant lesions was drawn, and the best limit value for the diagnosis of benign and malignant breast lesions was found. Results the K ~ (trans) values of normal gland group, benign lesion group and malignant lesion group were (0.224 卤0.136) min~ (-1), (0.539 卤0.242) min~ (-1), (1.371 卤0.709) min~ (-1) min~ _ (ep) (0.115 卤0.052) min~ (-1), (0.313 卤0.149) min~ (-1), (0.851 卤0.425) min~ (-1) respectively. The Ve values of benign lesion group and malignant lesion group were 0.186 卤0.096 卤0.240 卤0.175 卤0.212 卤0.140, respectively. The area under ROC curve of K ~ (trans) and K _ (ep) between benign and malignant lesions was 0.905 and 0.936 respectively, the best diagnostic threshold was 0.786 min~ (-1) and 0.410 min~ (-1), the diagnostic sensitivity was 81.3% and 93.8%, and the specificity was 80.0% and 83.3%, respectively. Conclusion KRRM model DCE-MRI is an effective quantitative method for the diagnosis of benign and malignant breast lesions, and the K ~ (trans) K _ (ep) value measured by DCE-MRI is stable and K ~ (trans) K _ (ep) value is very valuable for the diagnosis of benign and malignant breast diseases.
【作者单位】：北方民族大学(宁夏人民医院教学合作医院);
【基金】：国家民委科研项目(编号:14BFZ001) 宁夏回族自治区科技支撑计划项目(编号:2013ZYS109)
【分类号】：R445.2;R737.9

【相似文献】