DWI评价乳腺浸润性导管癌生物学特征

发布时间：2018-10-14 08:41

【摘要】：目的探讨DWI评估乳腺浸润性导管癌(IDC)生物学特征的价值。方法回顾性分析经手术病理证实的87个乳腺浸润性导管癌的DWI数据,测量ADC值,评价并比较ADC值在不同腋窝淋巴结状态、组织学级别及分子学分型间的差异,并分析ADC值与腋窝淋巴结状态、组织学级别及分子学分型的相关性。结果淋巴结阳性病灶ADC值低于淋巴结阴性病灶(P=0.035),高级别乳腺癌ADC值低于中级别、低级别乳腺癌(P=0.021、0.002),ADC值在不同分子分型间差异无统计学意义。ADC值与组织学分级呈低度负相关(r_s=-0.357,P=0.001),与腋窝淋巴结转移及分子分型呈弱的负相关(r_s=-0.227,P=0.034;r_s=-0.093,P0.001)。结论 DWI能够反映乳腺浸润性导管癌的生物学特征。
[Abstract]:Objective to evaluate the value of DWI in evaluating the biological characteristics of invasive ductal carcinoma of breast (IDC). Methods the DWI data of 87 invasive ductal carcinoma of breast proved by operation and pathology were analyzed retrospectively, ADC values were measured, and the differences of ADC values in different axillary lymph node status, histological grade and molecular credit type were evaluated and compared. The correlation between ADC and axillary lymph node status, histological grade and molecular credit type was analyzed. Results the ADC value of lymph node positive lesions was lower than that of lymph node negative lesions (P0. 035), and the ADC value of high grade breast cancer was lower than that of middle grade breast cancer. The low grade breast cancer (P0. 021 ~ 0. 002), ADC) had no significant difference among different molecular typing. The ADC value was negatively correlated with histological grade (rssi-0.357), and with axillary lymph node metastasis and molecular type (rs- 0. 227, P0.034, S / P 0. 093, P0. 001), and was negatively correlated with histological grade (rs0. 357) and axillary lymph node metastasis (rs0. 227p0. 034, P < 0. 093, P 0. 001). Conclusion DWI can reflect the biological characteristics of invasive ductal carcinoma of breast.
【作者单位】：中国医科大学附属第一医院放射科;中国医科大学基础学院数学系;
【基金】：辽宁省科技计划项目(2013225021)
【分类号】：R445.2;R737.9

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