老年维持性血液透析患者心理健康状况与神经营养因子的相关性
发布时间：2018-10-15 15:12
【摘要】：目的探讨老年维持性血液透析(MHD)患者心理健康状况与神经营养因子(NTF)的相关性。方法选择2014年1月至2015年1月在该院血液透析中心接受血液透析治疗的老年MHD患者228例及老年健康体检志愿者40例(对照组),采用抑郁自评量表(SDS)和焦虑自评量表(SAS)评价研究对象的抑郁和焦虑得分,采集清晨空腹血检测血红蛋白(Hb)、总蛋白(TP)、白蛋白(Alb)、前白蛋白(PA)、血肌酐(SCr)、血尿素氮(BUN)、血钙(Ca)、血磷(P)和脑源性NTF(BDNF)、神经营养因子3(NT-3),采用Logistic回归分析抑郁和焦虑与血清各指标的相关性。结果MHD患者抑郁和焦虑发生率显著高于对照组(P0.05);抑郁组和非抑郁组Hb、Tb、Alb、Ca、P水平均显著低于对照组(P0.05),Scr、BUN水平均显著高于对照组(P0.05)、焦虑组和非焦虑组Hb、Tb、Alb、Ca、P水平均显著低于对照组(P0.05),SCr、BUN、NT-3水平显著高于对照组(P0.05);影响抑郁得分的影响因子为Hb、BDNF和NT-3,影响焦虑得分的影响因子为NT-3。结论老年MHD患者抑郁、焦虑发病率显著高于正常人群,抑郁得分的影响因子是Hb、BDNF和NT-3,焦虑得分的影响因子是NT-3,在医疗实践中应该加强检测。
[Abstract]:Objective to investigate the correlation between mental health and neurotrophic factor (NTF) in elderly patients with maintenance hemodialysis (MHD). Methods from January 2014 to January 2015, 228 elderly MHD patients treated with hemodialysis and 40 healthy volunteers (control group) received hemodialysis from January 2014 to January 2015. Self-rating Depression scale (SDS) and Self-rating anxiety scale (SAS) were used. The depression and anxiety scores of the subjects were evaluated by (SAS). Fasting blood samples were collected to detect serum levels of (Hb), total protein, (TP), albumin, prealbumin, (PA), serum creatinine, (SCr), urea nitrogen, (BUN), serum calcium, (Ca), phosphorus (P) and brain-derived NTF (BDNF), neurotrophic factor 3 (NT-3). Logistic regression analysis was used to analyze the correlation between depression and anxiety and serum indexes. Results the incidence of depression and anxiety in patients with MHD was significantly higher than that in control group (P0.05), the level of Hb,Tb,Alb,Ca,P in depression group and non-depression group was significantly lower than that in control group (P0.05), the level of Scr,BUN was significantly higher than that in control group (P0.05), and the Hb,Tb,Alb,Ca,P level in anxiety group and non-anxiety group was significantly lower than that in control group (P0.05). In the group (P0.05), the level of SCr,BUN,NT-3 was significantly higher than that in the control group (P0.05), and the influencing factors of depression score were Hb,BDNF and NT-3, the influencing factors of anxiety score were NT-3.. Conclusion the incidence of depression and anxiety in elderly patients with MHD is significantly higher than that in normal subjects. The influencing factors of depression scores are Hb,BDNF and NT-3, anxiety scores. NT-3, should be strengthened in medical practice.
【作者单位】： 首都医科大学附属北京朝阳医院西院;
【分类号】：R473.5
本文编号：2272936
[Abstract]:Objective to investigate the correlation between mental health and neurotrophic factor (NTF) in elderly patients with maintenance hemodialysis (MHD). Methods from January 2014 to January 2015, 228 elderly MHD patients treated with hemodialysis and 40 healthy volunteers (control group) received hemodialysis from January 2014 to January 2015. Self-rating Depression scale (SDS) and Self-rating anxiety scale (SAS) were used. The depression and anxiety scores of the subjects were evaluated by (SAS). Fasting blood samples were collected to detect serum levels of (Hb), total protein, (TP), albumin, prealbumin, (PA), serum creatinine, (SCr), urea nitrogen, (BUN), serum calcium, (Ca), phosphorus (P) and brain-derived NTF (BDNF), neurotrophic factor 3 (NT-3). Logistic regression analysis was used to analyze the correlation between depression and anxiety and serum indexes. Results the incidence of depression and anxiety in patients with MHD was significantly higher than that in control group (P0.05), the level of Hb,Tb,Alb,Ca,P in depression group and non-depression group was significantly lower than that in control group (P0.05), the level of Scr,BUN was significantly higher than that in control group (P0.05), and the Hb,Tb,Alb,Ca,P level in anxiety group and non-anxiety group was significantly lower than that in control group (P0.05). In the group (P0.05), the level of SCr,BUN,NT-3 was significantly higher than that in the control group (P0.05), and the influencing factors of depression score were Hb,BDNF and NT-3, the influencing factors of anxiety score were NT-3.. Conclusion the incidence of depression and anxiety in elderly patients with MHD is significantly higher than that in normal subjects. The influencing factors of depression scores are Hb,BDNF and NT-3, anxiety scores. NT-3, should be strengthened in medical practice.
【作者单位】： 首都医科大学附属北京朝阳医院西院;
【分类号】：R473.5
【相似文献】
相关期刊论文 前1条
1 程世斌;神经营养因子临床给药的新方法[J];生理科学进展;1995年02期
，本文编号：2272936
本文链接：https://www.wllwen.com/linchuangyixuelunwen/2272936.html
最近更新
教材专著
