淄博地区常见多重耐药菌的临床分布及耐药性分析

发布时间：2018-10-31 08:37

【摘要】：目的分析淄博地区多重耐药菌(multi-drug resistant organism,MDRO)的临床分布及耐药性,为地区性预防和控制MDRO的医院感染提供科学依据。方法回顾性分析淄博地区14家医院在2013年8月-2015年12月检出的2 570株多重耐药菌,采用法国梅里埃VITEK 2微生物鉴定和药敏系统对MDRO进行菌种鉴定和药敏检测。结果 2 570株多重耐药菌中,革兰阴性杆菌2 353株(91.56%),其中以产超广谱β-内酰胺酶(ESBLs)的大肠埃希菌居首位(1 002株,38.99%),革兰阳性球菌(217株,8.44%)均为耐甲氧西林金黄色葡萄球菌(MRSA)。临床分离MDRO的科室主要为ICU(36.07%)和呼吸内科(10.58%)。耐碳青酶烯类的肠杆菌科细菌和鲍曼不动杆菌对临床常用抗菌药物的耐药率均在90%以上,尚未发现万古霉素耐药的金黄色葡萄球菌。结论淄博地区常见MDRO主要分离自收治重症和高龄患者的科室,需加强对高危科室和易感人群的监控并采取有效的感染控制措施,以遏制多重耐药菌的播散。
[Abstract]:Objective to analyze the clinical distribution and drug resistance of multidrug resistant bacteria (multi-drug resistant organism,MDRO) in Zibo area, and to provide scientific basis for the prevention and control of nosocomial infection of MDRO. Methods A retrospective analysis was made on 2 570 strains of multidrug resistant bacteria detected in 14 hospitals in Zibo from August 2013 to December 2015. The strain identification and drug sensitivity test of MDRO were performed by VITEK 2 microorganism identification and drug sensitivity system in France. Results among the 2 570 multidrug resistant strains, 2 353 strains (91.56%) were Gram-negative bacilli, among which Escherichia coli producing extended-spectrum 尾 -lactamase (ESBLs) (1 002 strains, 38.99%) and gram-positive coccus (217 strains) were the first. 8.44%) were all methicillin-resistant Staphylococcus aureus (MRSA). ICU (36.07%) and Department of Respiratory Medicine (10.58%) were the main departments of clinical MDRO isolation. The resistance rates of enterobacteriaceae and Acinetobacter baumannii to common antibiotics were over 90%, but vancomycin resistant Staphylococcus aureus was not found. Conclusion the common MDRO in Zibo area is mainly isolated from the departments of severe and elderly patients. It is necessary to strengthen the surveillance of high-risk departments and susceptible populations and to take effective infection control measures to curb the spread of multidrug resistant bacteria.
【作者单位】：淄博市中心医院检验科;淄博市中心医院中心实验室;
【基金】：山东省自然科学基金(ZR2015HM031)
【分类号】：R446.5

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