1138株金黄色葡萄球菌耐药性分析

发布时间：2018-11-10 12:09

【摘要】：目的分析某医院1 138株金黄色葡萄球菌分离株的分布特点及耐药状况。方法选择1 138株2012~2014年分离的金黄色葡萄球菌分离株。分离株主要来自痰液(360株、31.6%)、伤口分泌物(272株、23.9%)和其他分泌物株(205株、18.0%),科室主要来自烧伤科(278株、24.4%)、儿科(116株、10.2%)、耳鼻喉科(114株、10.0%)。采用纸片扩散法进行药敏实验,分析其耐药情况。结果 1 138株金黄色葡萄球菌分离株中耐甲氧西林金黄色葡萄球菌(MRSA)457株(40.2%)、甲氧西林敏感金黄色葡萄球菌(MSSA)681株(59.8%)。MRSA对青霉素G、头孢呋辛、头孢噻肟、头孢唑啉、苯唑西林的耐药率均为100%,而MSSA分别为6.3%、7.6%、8.1%、0、7.3%,MRSA耐药率高于MSSA(P均0.05)。结论院内分离的金黄色葡萄球菌菌株中MRSA检出率较高,且多重耐药菌株多见。临床医生需根据菌株药敏结果合理使用抗菌药物。
[Abstract]:Objective to analyze the distribution and drug resistance of 1 138 Staphylococcus aureus isolates in a hospital. Methods 1 138 Staphylococcus aureus isolates from 2012 to 2014 were selected. The isolates were mainly from sputum (360 strains, 31.6%), wound secretions (272 strains, 23.9%) and other secretions (205 strains, 18.0%). Otorhinolaryngology (114 strains, 10.0%). The drug sensitivity test was carried out by disk diffusion method, and the drug resistance was analyzed. Results among 1 138 isolates of Staphylococcus aureus, 457 strains (40.2%) were methicillin-resistant Staphylococcus aureus and 681 (59.8%). MRSA were methicillin-sensitive Staphylococcus aureus against penicillin G and cefuroxime. The drug resistance rates of cefotaxime, cefazolin and oxacillin were 100, while MSSA were 6.3and 7.6and 8.1cm, respectively. The resistance rate of MSSA was higher than that of MSSA (P. Conclusion the detection rate of MRSA in Staphylococcus aureus strains isolated in hospital is high, and multidrug resistant strains are more common. The clinical doctor should use the antibiotics reasonably according to the drug sensitivity result of the strain.
【作者单位】：宁夏医科大学临床学院;甘肃省人民医院检验中心;甘肃省中医药大学;
【基金】：甘肃省卫生行业科研基金资助项目(GSWST2012-04)
【分类号】：R446.5

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