山东省101所医院重症监护病房患者分离细菌及耐药性特征

发布时间：2018-11-27 06:38

【摘要】：目的了解山东省重症监护病房(ICU)细菌分布及耐药情况。方法收集2014年山东省101所医院ICU及106所医院普通病房(非ICU)分离细菌的药敏数据,进行统计分析。结果共收集细菌24 458株,革兰阴性菌占80.37%,革兰阳性菌占19.63%。ICU分离居前5位的细菌依次为:肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌、大肠埃希菌、金黄色葡萄球菌。来源于ICU的大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌、黏质沙雷菌对碳青霉烯类药物、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、阿米卡星耐药率高于非ICU来源菌株(均P0.01)。ICU分离鲍曼不动杆菌、铜绿假单胞菌、葡萄球菌属细菌对常用抗菌药物耐药率高于非ICU菌株(P0.05)。ICU分离鲍曼不动杆菌对亚胺培南和美罗培南耐药率分别为78.0%、79.0%;铜绿假单胞菌对前述药物耐药率分别为25.5%、21.6%,对其他常用抗菌药物的耐药率30.0%。ICU耐甲氧西林金黄色葡萄球菌(MRSA)检出率为39.7%,高于非ICU的26.0%(P0.05)。结论 ICU分离细菌耐药情况比较严重,应依据药敏结果指导抗菌药物合理应用,防止耐药菌感染扩散。
[Abstract]:Objective to investigate the distribution and drug resistance of (ICU) bacteria in intensive care unit (ICU) of Shandong Province. Methods Drug susceptibility data of bacteria isolated from 101 hospitals in Shandong Province in 2014, ICU and 10 6 hospitals in general wards (non-ICU) were collected and analyzed statistically. Results A total of 24,458 strains of bacteria were collected, gram-negative bacteria accounted for 80.37, Gram-positive bacteria accounted for the top 5 bacteria isolated from 19.63%.ICU, followed by Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli. Staphylococcus aureus Escherichia coli from ICU, Klebsiella pneumoniae, Enterobacter cloacae, Myxobacterium Shareh against carbapenem, piperacillin / tazobactam, cefoperazone / sulbactam, The drug resistance rate of amikacin was higher than that of non-ICU strains (P0.01). ICU and Pseudomonas aeruginosa). The resistance rate of staphylococcal bacteria to common antimicrobial agents was higher than that of non-ICU strains (P0.05). The resistant rates of Acinetobacter baumannii to imipenem and meropenem were 78.0% and 79.0%, respectively. The drug resistance rates of Pseudomonas aeruginosa to the aforementioned drugs were 25.51.60.The rates of resistance to other commonly used antibiotics were 39.7% for methicillin-resistant Staphylococcus aureus (MRSA), and 39.7% for methicillin resistant Staphylococcus aureus (MRSA). It was higher than 26.0% of non-ICU (P0.05). Conclusion the drug resistance of bacteria isolated by ICU is serious, so the rational use of antimicrobial agents should be guided according to the results of drug sensitivity to prevent the spread of drug-resistant bacteria infection.
【作者单位】：山东大学附属省立医院;
【分类号】：R446.5

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