HIFU焦域的温度分布模拟及其疗效分析

发布时间：2018-12-16 17:26

【摘要】：高强度聚焦超声(HIFU)是一种非侵入性、对正常组织无损伤且不易引起癌细胞转移的肿瘤治疗手段,对其治疗过程中的疗效以及肿瘤周围正常组织破坏情况的监测是实现HIFU治疗剂量精准控制的关键.本文首先从HIFU局部组织加热出发,建立了HIFU治疗系统模型,利用有限元数值模拟了HIFU焦域的声场以及温度场分布,并研究了换能器参数、超声功率、治疗时间对焦域温度分布的影响.结果表明,随着治疗时间的增长,焦点温度上升,逐渐形成椭球状的焦域;在达到治疗疗效时,即焦域径向±0.4 mm椭球范围内的组织温度达到了343 K(70℃)时,随着换能器结构系数(半径/焦距)的减小,所需要的治疗时间增长,所形成的焦域不断扩大,其轴向宽度与径向宽度比值增大,焦域变得细长,焦点处的温度逐渐降低.本研究对已知结构系数的聚焦换能器的焦域温度场仿真,可以为HIFU治疗中的温度估计和监控提供新方法,也可为疗效评估和剂量控制提供新技术.
[Abstract]:High intensity focused ultrasound (HIFU) is a non-invasive, non-invasive and non-invasive method for cancer cell metastasis. The monitoring of the therapeutic effect and the damage of normal tissue around the tumor is the key to the accurate control of the dose of HIFU. In this paper, the model of HIFU treatment system is established based on the local tissue heating of HIFU. The acoustic field and temperature distribution in the focal region of HIFU are numerically simulated by finite element method, and the transducer parameters and ultrasonic power are studied. Effect of treatment time on temperature distribution in focal region. The results showed that with the increase of treatment time, the focal temperature increased and the ellipsoidal focal region gradually formed. When the therapeutic effect was achieved, that is, the tissue temperature in the radius 卤0.4 mm ellipsoid reached 343K (70 鈩，

本文编号：2382762