7项指标在牙周炎患者血清及龈沟液中的表达

发布时间：2018-12-17 11:25

【摘要】：目的检测牙周炎患者血清及龈沟液中基质金属蛋白酶(MMP)、高迁移率族蛋白(HMGB)、趋化因子CX3CL1、趋化因子CCL11及白细胞介素(IL)-1β的变化,为牙周炎的靶向治疗提供依据。方法随机选择2016年1-5月在该院诊治的牙周炎患者20例作为患者组,选取同期健康体检者20例作为对照组。检测血清及龈沟液中MMP-4、MMP-5、HMGB2、HMGB1、CX3CL1、CCL11及IL-1β的水平。结果患者组血清MMP-4、MMP-5、HMGB2、HMGB1、CX3CL1、CCL11及IL-1β平均水平分别为(563.64±62.27)pg/mL、(615.36±70.44)pg/mL、(564.65±57.38)pg/mL、(481.33±51.42)pg/mL、(53.47±6.14)pg/mL、(41.20±4.16)pg/mL和(47.84±10.18)pg/mL,均高于对照组,差异有统计学意义(P0.05);患者组龈沟液MMP-4、MMP-5、HMGB2、HMGB1、CX3CL1、CCL11及IL-1β平均水平分别为(830.58±86.31)pg/mL、(793.47±81.65)pg/mL、(766.52±68.44)pg/mL、(801.69±75.36)pg/mL、(50.89±6.02)pg/mL、(44.52±5.21)pg/mL、和(53.61±10.29)pg/mL,均高于对照组,差异有统计学意义(P0.05)。结论牙周炎患者血清及龈沟液中MMP-4、MMP-5、HMGB2、HMGB1、CX3CL1、CCL11及IL-1β均显著上升,趋势呈一致性,与牙周炎的发生发展有关。
[Abstract]:Objective to detect the changes of matrix metalloproteinase (MMP),) (MMP), high mobility group protein (HMGB), chemokine (HMGB),) chemokine CCL11 and interleukin (IL) 1 尾 in serum and gingival crevicular fluid of patients with periodontitis. To provide the basis for the targeted treatment of periodontitis. Methods Twenty patients with periodontitis treated in our hospital from January to May 2016 were randomly selected as the patient group and 20 healthy persons as the control group. The levels of MMP-4,MMP-5,HMGB2,HMGB1,CX3CL1,CCL11 and IL-1 尾 in serum and gingival crevicular fluid were measured. Results the average levels of serum MMP-4,MMP-5,HMGB2,HMGB1,CX3CL1,CCL11 and IL-1 尾 were (563.64 卤62.27) pg/mL, (615.36 卤70.44) pg/mL, (564.65 卤57.38) pg/mL, (481.33 卤51.42) pg/mL, respectively. (53.47 卤6.14) pg/mL, (41.20 卤4.16) pg/mL and (47.84 卤10.18) pg/mL, were significantly higher than those in the control group (P0.05). The average levels of MMP-4,MMP-5,HMGB2,HMGB1,CX3CL1,CCL11 and IL-1 尾 in gingival crevicular fluid were (830.58 卤86.31) pg/mL, (793.47 卤81.65) pg/mL, (766.52 卤68.44) pg/mL, (801.69 卤75.36) pg/mL, respectively. (50.89 卤6.02) pg/mL, (44.52 卤5.21) pg/mL, and (53.61 卤10.29) pg/mL, were significantly higher than those in the control group (P0.05). Conclusion MMP-4,MMP-5,HMGB2,HMGB1,CX3CL1,CCL11 and IL-1 尾 in serum and gingival crevicular fluid in patients with periodontitis were significantly increased, and the trend was consistent, which was related to the occurrence and development of periodontitis.
【作者单位】：广东省深圳市龙岗区第四人民医院检验科;广东省深圳市龙岗区第四人民医院口腔科;
【基金】：广东省深圳市龙岗区科技发展资金项目(YS2013189)
【分类号】：R781.42;R446.1

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