预存式自体输血对择期手术患者术后淋巴细胞亚群的影响

发布时间：2018-12-20 16:05

【摘要】：目的评价预存式自体输血对择期手术患者术后免疫功能的影响。方法选择本院2015年11月-2016年8月符合预存式自体输血指征的择期手术患者51名,分为自体血组(n=20):术前采集自体血、术中回输;异体血组(n=15):术前未预存自体血,术中输异体血。未输血组(n=16):术前未预存自体血,术中未输注异体血。分析比较3组患者术前、术后1 d和5 d CD3+、CD4+、CD8+、CD4+/CD8+和NK细胞的变化。结果术后1 d,CD3+(%)、CD4+(%)及NK细胞数(×109),自体血组较异体血组与未输血组分别为59.81±5.82 vs 50.04±4.37 vs 56.28±5.56,31.06±5.77 vs 22.88±3.80 vs 29.00±2.77,0.17±0.06 vs 0.12±0.05 vs 0.17±0.05,自体血组较异体血组明显升高(P0.05);术后5 d CD3+(%)、CD4+(%)、CD4/CD8、NK细胞比例(%)及绝对计数(×109),自体血组、异体血组与未输血组分别为69.56±6.02 vs 59.81±5.38 vs 67.93±7.89,42.91±6.08 vs 31.14±3.99 vs 43.40±3.31,1.73±0.36 vs 1.23±0.37 vs 1.77±0.46,12.53±4.33 vs 7.84±3.41 vs 12.11±3.72,0.21±0.11 vs 0.10±0.06 vs 0.18±0.06),自体血组较异体血组明显升高(P0.05)。结论预存式自体输血较异体输血对于患者术后免疫功能影响较小,对细胞免疫功能有正向调节作用。
[Abstract]:Objective to evaluate the effect of preexisting autologous blood transfusion on postoperative immune function in patients undergoing elective operation. Methods from November 2015 to August 2016, 51 patients were selected and divided into autologous blood group (n = 20) and autologous blood group (n = 20). Autologous blood was collected before operation and reinfused during operation. Allogeneic blood group (nm15): no autologous blood was stored before operation and allogeneic blood was infused during operation. No autologous blood was prestored before operation and allogeneic blood was not infused during operation in no transfusion group (n = 16). The changes of CD3, CD4, CD8, CD4 / CD8 and NK cells before and after operation were analyzed and compared in three groups. Results 1 day after operation, CD3 (%), CD4 (%) and the number of NK cells (脳 10 ~ 9) were found. Autologous blood group was 59.81 卤5.82 vs 50.04 卤4.37 vs 56.28 卤5.56 vs 31.06 卤5.77 vs 22.88 卤3.80 vs 29.00 卤2.77 vs 0.17 卤0.06 vs 0.12 卤0.05 vs 0.17 卤0.05 vs respectively. Autologous blood group was significantly higher than that of allogeneic blood group (P0.05). CD3 (%), CD4 (%), percentage of CD4/CD8,NK cells (%) and absolute count (脳 10 ~ 9) were found in autologous blood group 5 days after operation. The vs of allogeneic blood group and non-transfusion group were 69.56 卤6.02 vs 59.81 卤5.38 vs 67.93 卤7.89 vs 42.91 卤6.08 vs 31.14 卤3.99 vs 43.40 卤3.31 vs 1.73 卤0.36 vs 1.23 卤0.37 vs 1.77 卤0.4612.53 卤4.33 vs 7.84 卤3.33 respectively. 41 vs 12.11 卤3.72 vs 0.21 卤0.11 vs 0.10 卤0.06 vs 0.18 卤0.06). Autologous blood group was significantly higher than that of allogeneic blood group (P0.05). Conclusion Preexisting autologous blood transfusion has less effect on postoperative immune function than allogeneic blood transfusion, and has a positive effect on cellular immune function.
【作者单位】： 陆军总医院输血科陆军血液中心;陆军总医院附属八一儿童医院儿童血液肿瘤科;
【基金】：北京市科技计划课题首都临床特色应用研究”专项(Z161100000516166)
【分类号】：R457.1
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