新疆柯尔克孜族献血者7个红细胞血型系统抗原基因多态性分析

发布时间：2019-01-26 16:21

【摘要】：目的了解新疆柯尔克孜族人各种(类)红细胞血型系统抗原基因的多态性分布情况。方法采用PCRSSP方法对113名新疆柯尔克孜族无血缘关系的健康献血者Kell、Duffy、Diego、Kidd、Dombrock、Yt和Colton 7个血型系统做基因分型,并做基因多态性分析。结果本组新疆柯尔克孜族无偿献血者人群的Kell、Duffy、Diego、Kidd、Dombrock、Yt和Colton7个血型系统抗原基因频率分别为K=0.008 8(2/226)、k=0.991 2(224/226),Jsa=1.000 0(226/226)、Jsb=0.000 0(0/226),Fya=0.725 7(164/226)、Fyb=0.274 3(62/226),Dia=0.057 5(13/226)、Dib=0.942 5(213/226),Jka=0.615 0(139/226)、Jkb=0.385 0(87/226),Doa=0.238 9(54/226)、Dob=0.761 1(172/226),Yta=0.946 9(214/226)、Ytb=0.053 1(12/226),Coa=1.000 0(226/226)、Cob=0.000 0(0/226),均符合Hardy-Weinberg遗传定律(P0.05),Kell和Colton基因分布与汉族、维吾尔族、回族、藏族、满族人群相似。结论新疆柯尔克孜族人Duffy、Diego、Kidd、Dombrock和Yt血型系统基因频率具有独特的分布特点,Kell和Colton血型系统与国内许多民族相似;Colton血型系统基因呈单态性分布。
[Abstract]:Objective to investigate the polymorphism distribution of erythrocyte blood group system antigen genes in Kirgiz nationality of Xinjiang. Methods the genotyping of Kell,Duffy,Diego,Kidd,Dombrock,Yt and Colton blood groups in 113 unrelated healthy blood donors from Kirgiz nationality in Xinjiang were performed by PCRSSP, and the genetic polymorphisms were analyzed. Results the frequencies of Kell,Duffy,Diego,Kidd,Dombrock,Yt and Colton7 antigens were 0.008 8 (2 / 226), 0.991 2 (224 / 226), Jsa=1.000 0 (226 / 226), respectively. Jsb=0.000 0 (0 / 226), Fya=0.725 7 (164 / 226), Fyb=0.274 3 (62 / 226), Dia=0.057 5 (13 / 226), Dib=0.942 5 (213 / 226), Jka=0.615 0 (139 / 226), Jkb=0.385 0 (87 / 226). Doa=0.238 9 (54 / 226), Dob=0.761 1 (172 / 226), Yta=0.946 9 (214 / 226), Ytb=0.053 1 (12 / 226), Coa=1.000 0 (226 / 226), Cob=0.000 0 (0 / 226), all conform to the Hardy-Weinberg genetic law (P0.05). The distribution of Kell and Colton gene was similar to that of Han, Uygur, Hui, Tibetan and Manchu. Conclusion the gene frequencies of Duffy,Diego,Kidd,Dombrock and Yt blood group system in Kirgiz nationality of Xinjiang have unique distribution characteristics, the Kell and Colton blood group systems are similar to those of many nationalities in China, and the gene distribution of Colton blood group system is monomorphic.
【作者单位】：乌鲁木齐市血液中心;喀什地区第一人民医院;克孜勒苏柯尔克孜自治州中心血站;
【基金】：新疆维吾尔自治区自然科学基金(2015211A009)
【分类号】：R457.11

【相似文献】