生脉注射液在高龄感染性休克患者中的应用价值及对内皮素1和一氧化氮表达的影响

发布时间：2019-03-26 17:52

【摘要】：目的对应用生脉注射液治疗高龄感染性休克患者的临床效果进行分析,并系统探讨对ET-I、NO表达影响,为临床合理用药提供依据。方法选取2015年2月-2016年2月医院收治的高龄感染性休克患者75例纳入本研究,通过随机数字表法分成探究组39例和对照组36例;对照组进行常规专科治疗,探究组则同时应用生脉注射液,治疗完成后,对两组临床效果及血生化试验结果进行比较分析。结果探究组的临床总有效率为87.8%,对照组为60.2%,两组比较差异有统计学意义(P0.05);在治疗结束后进行血生化检测,探究组患者的血清C-反应蛋白(CRP)、降钙素原(PCT)、内皮素1(ET-1)、一氧化氮(NO)均比对照组低,但ET-1/NO要高于对照组,差异均有统计学意义(P0.05)。结论在高龄感染性休克患者治疗中,应用生脉注射液效果确切,可有效改善患者病情,降低CRP、PCT等指标,且可对ET-1、NO过度产生有抑制效用,临床应用价值重大。
[Abstract]:Aim to analyze the clinical effects of Shengmai injection on the expression of ET-I,NO in elderly patients with septic shock, and to provide evidence for rational use of drugs. Methods from February 2015 to February 2016, 75 elderly patients with septic shock were enrolled in this study. They were randomly divided into two groups (n = 39) and control group (n = 36). The patients in the control group were treated with routine specialized therapy, and the patients in the exploratory group were treated with Shengmai injection at the same time. After the treatment, the clinical effects and the results of blood biochemical tests between the two groups were compared and analyzed. Results the total clinical effective rate was 87.8% in the inquiry group and 60.2% in the control group. There was a significant difference between the two groups (P0.05). After treatment, the serum C-reactive protein (CRP), procalcitonin (PCT), endothelin-1 (ET-1) and nitric oxide (NO) were lower than those in the control group, but the level of ET-1/NO was higher than that in the control group. The difference was statistically significant (P0.05). Conclusion in the treatment of elderly patients with septic shock, Shengmai injection has a definite effect, can effectively improve the patient's condition, reduce CRP,PCT and other indexes, and can inhibit the over-production of ET-1,NO, which is of great value in clinical application.
【作者单位】：武汉市第一医院急诊科;
【分类号】：R459.7

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