心肺复苏术后患者高铁血红蛋白水平的回顾性研究
发布时间:2019-05-12 04:18
【摘要】:目的:研究心肺复苏术后患者高铁血红蛋白(MetHb)水平,探讨其与心肺复苏术后患者的病情及早期预后的关系。方法:对广西医科大学第一附属医院ICU二区2013年8月至2016年3月期间66例心肺复苏术后患者进行回顾性分析。记录患者的年龄、性别、基础疾病、心脏骤停原因、心肺复苏时间等临床资料及入ICU时的高铁血红蛋白水平,同时记录患者入ICU 24小时内的急性生理学与慢性健康状况评分系统Ⅱ (APACHE Ⅱ)评分、序贯性器官功能衰竭(SOFA)评分。观察终点是入ICU第7天的治疗结局。根据入ICU第7天的治疗结局将患者分为7天死亡组和存活组,比较两组的高铁血红蛋白水平,用双变量相关分析评价高铁血红蛋白与各变量的相关性,用多因素Logistic回归、受试者工作特征曲线(ROC曲线)评价高铁血红蛋白对心肺复苏患者预后判断的价值。结果:①66例心肺复苏患者入选,其中7天生存组32例,死亡组34例,两组患者的基线资料均衡,具有可比性。②66例患者高铁血红蛋白水平(%)0.4-2.8(1.15±0.47),死亡组比存活组高(1.34±0.54 vs 0.94±0.26,P0.01)。③相关分析显示,高铁血红蛋白水平与SOFA评分(r=0.449,P0.001)、APACHE Ⅱ评分(r=0.264,P0.05)、乳酸(r=0.376,P0.001),呈显著正相关,与PH(r=-0.540,P0.001)、BE(r=-0.477,P0.01)、Hb(r=-0.495,P0.01)显著负相关。④多因素Logistic回.归分析显示:BE、高铁血红蛋白、乳酸是预测心肺复苏患者7天死亡风险的独立危险因素,相对危险度(OR值)分别为1.175、 1.213、 1.384(P0.05)。⑤ROC曲线分析显示:高铁血红蛋白的ROC曲线下面积为0.748(0.632~0.865),预测7天死亡的最佳截断值为1.25%,其敏感度为44.1%,特异性为93.7%。结论:本研究显示了升高的高铁血红蛋白水平与心肺复苏术后患者病情严重程度和不良预后之间的相关性,测定心肺复苏术后患者的高铁血红蛋白水平,可以为早期预后判断提供参考。
[Abstract]:Objective: to study the level of methemoglobin (MetHb) in patients after cardiopulmonary resuscitation (CPR) and its relationship with the condition and early prognosis of patients after cardiopulmonary resuscitation (CPR). Methods: 66 patients with cardiopulmonary resuscitation from August 2013 to March 2016 in ICU area II, the first affiliated Hospital of Guangxi Medical University, were analyzed retrospectively. the results showed that 66 patients with cardiopulmonary resuscitation (CPR) were treated with cardiopulmonary resuscitation from August 2013 to March 2016. The clinical data of the patients, such as age, sex, basic disease, causes of cardiac arrest, cardiopulmonary resuscitation time and methemoglobin levels at the time of ICU entry, were recorded. At the same time, acute physiology and chronic health status scoring system II (APACHE 鈪,
本文编号:2475099
[Abstract]:Objective: to study the level of methemoglobin (MetHb) in patients after cardiopulmonary resuscitation (CPR) and its relationship with the condition and early prognosis of patients after cardiopulmonary resuscitation (CPR). Methods: 66 patients with cardiopulmonary resuscitation from August 2013 to March 2016 in ICU area II, the first affiliated Hospital of Guangxi Medical University, were analyzed retrospectively. the results showed that 66 patients with cardiopulmonary resuscitation (CPR) were treated with cardiopulmonary resuscitation from August 2013 to March 2016. The clinical data of the patients, such as age, sex, basic disease, causes of cardiac arrest, cardiopulmonary resuscitation time and methemoglobin levels at the time of ICU entry, were recorded. At the same time, acute physiology and chronic health status scoring system II (APACHE 鈪,
本文编号:2475099
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