海南省219株耐药结核分枝杆菌药敏试验结果分析

发布时间：2019-06-16 18:27

【摘要】：目的分析海南省结核病医院502株结核菌株的耐药类型及分布情况,为制定耐药结核病治疗方案提供科学依据。方法收集2014年1月至2016年12月期间收治的经痰分离培养并鉴定为结核分枝杆菌复合群的共502株菌株,进行8种抗结核药物(异烟腆、利福平、乙胺丁醇、链霉素、卡那霉素、卷曲霉素、氧氟沙星以及丙硫异烟胺)的药物敏感性试验,对其结果进行分析。结果总耐药率为43.6%(219/502),2015、2016年总耐药率明显高于2014年(=10.136,P=0.001;=8.56,P=0.003);总耐多药率为25.5%(128/502),近3年耐多药疫情无明显变化(=3.297,P0.05);抗结核药物耐药率由高到低依次为利福平异烟肼链霉素氧氟沙星乙胺丁醇卡那霉素卷曲霉素丙硫异烟胺;耐药类型以耐多药和利福平耐药为主。结论海南省耐药结核病尤其是耐多药结核病形势不容乐观;乙胺丁醇、卡那霉素、卷曲霉素、丙硫异烟胺在海南地区仍有很大的临床抗结核价值,临床上应予以关注;应继续加强耐药结核病发现力度和防控策略,遏制耐药结核病流行。
[Abstract]:Objective to analyze the drug resistance types and distribution of 502 strains of tuberculosis in Hainan Tuberculosis Hospital, and to provide scientific basis for the formulation of drug-resistant tuberculosis treatment plan. Methods A total of 502 strains isolated and cultured from sputum from January 2014 to December 2016 were collected and identified as Mycobacterium tuberculosis complex. The drug sensitivity tests of 8 kinds of anti-tuberculosis drugs (isomorphism, rifampicin, ethambutol, streptomycin, kanamycin, capritin, ofloxacin and prothionicamine) were carried out and the results were analyzed. Results the total drug resistance rate was 43.6% (219 鈮，

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