替加环素不良反应的文献计量分析

发布时间：2017-12-30 18:09

本文关键词：替加环素不良反应的文献计量分析　出处：《中国新药杂志》2017年19期 　论文类型：期刊论文

【摘要】：目的:探究替加环素所致不良反应(ADRs)的发生规律及临床特点,促进临床安全合理用药。方法:以“替加环素、“不良反应”等为关键字,在中华医院知识仓库(CNKD)期刊全文数据库、万方数据库、维普中文科技期刊数据库、中华医学会期刊自建数据库、中国知网(CNKI)检索1997—2016年有关替加环素不良反应的文献,并以“tigecycline”,“adverse drug reactions”等为检索词在Pubmed和Elsevier Clinicalkey进行上述检索,对其进行统计分析。结果:共检索到文献1 439篇,排除综述、同一病例的重复报道及其余交代不清的报道,共有符合标准的文献44篇(国外27篇,国内17篇),病例169例。替加环素所致ADRs及其临床表现复杂多样,其中以急性胰腺炎、凝血功能障碍为主,其他还包括血细胞减少、腹泻、皮疹、肝损伤、肾损伤等。结论:替加环素所引起的ADRs日益增多,可累及全身多个系统,应引起临床高度重视。
[Abstract]:Objective: to investigate the occurrence and clinical characteristics of adverse reactions induced by tegacycline (ADRs) and to promote clinical safety and rational use of ADRs.Methods: the keywords of "tegacyclin" and "adverse reactions" were used as the keywords. In the Chinese hospital knowledge warehouse CNKDjournal full text database, Wanfang database, Weipu Chinese science and technology periodical database, the Chinese medical association periodical self-built database. The literature on adverse reactions of tegacycline from 1997 to 2016 was searched by CNKI and used as "tigecycline". "adverse drug reactions" was used for the above search in Pubmed and Elsevier Clinicalkey. Results: a total of 1 439 papers were retrieved, excluding reviews, repeated reports of the same case and other unclear reports. There were 44 articles that met the standard (27 papers abroad). There were 17 cases (169 cases) in China. ADRs caused by tegacycline and its clinical manifestations were complicated and varied, including acute pancreatitis, coagulation dysfunction, and others including hematopenia, diarrhea and rash. Conclusion: the number of ADRs caused by tegacycline is increasing day by day, which can involve many systems of the whole body, and should be paid more attention in clinic.
【作者单位】：中国医科大学附属盛京医院药学部;
【分类号】：G353.1;R978
【正文快照】： 替加环素(tigecyclin)是全球首个被批准用于静脉注射的新一代甘氨酰环素类抗生素,其结构与四环素类药物类似。替加环素的抗菌谱广,对有耐药性的致病菌,特别是泛耐药致病菌如耐甲氧西林金黄色葡萄球菌(methicillin resistant staphylococcusaureus,MRSA)、耐万古霉素肠球菌(van

【相似文献】