传统中药益母草全背景研究的文献计量学分析

发布时间：2018-04-04 05:26

本文选题：益母草　切入点：益母草注射液　出处：《中国循证医学杂志》2017年01期

【摘要】：目的采用文献计量学方法分析传统中药益母草的研究现状和在疾病防治中的应用。方法计算机检索CBM、CNKI、Wan Fang Data、EMbase和Ovid(MEDLINE)数据库,搜集益母草相关的研究文献,检索时间均从建库至2016年8月26日。按发表时间、发表杂志、文献主题、益母草剂型等对文献进行筛选和分类,分析和评价益母草文献研究现状及其在疾病中的应用。结果共纳入益母草相关文献7 040篇,其中:益母草饮片文献4 653篇,中成药文献1 017篇,原料药文献648篇,兽医学文献722篇。益母草相关的中成药研究文献量呈三段式增长,发表量居前12位的杂志均为中文期刊,发表文献中出现频次最高的前三种中成药剂型分别是冲剂/颗粒、注射液和胶囊。中成药文献中报道益母草注射液263篇,含48篇基础研究,主要涉及子宫收缩、降低全血黏度、改善心肌缺血及其再灌注损伤、改善淋巴微循环等的作用;临床研究211篇,涉及产后出血和流产后出血,冠心病、脑梗塞、心力衰竭、心肌缺血等。结论益母草中成药文献远少于传统中药汤剂研究。冲剂/颗粒及注射液可能是益母草在临床使用中的优势剂型。产后出血可能是益母草注射液在临床使用中的优势病种。益母草注射液有多种药理作用,但临床研究文献证据级别较低,急需进一步深入开展高质量临床研究,为益母草注射液的临床实践提供高质量证据。
[Abstract]:Objective to analyze the current situation of traditional Chinese medicine Leonurus chinensis and its application in disease prevention and control by bibliometrics.Methods the databases of Fang Fang EMbase and Ovidr MEDLINE were searched by computer, and the related literatures of Leonurus were collected. The retrieval time was from the establishment of the database to August 26, 2016.According to the time of publication, the publication of magazines, the subject of literature, the form of Leonurus and so on, to screen and classify the literature, analyze and evaluate the current situation of the literature of Leonurus and its application in diseases.Results A total of 7 040 articles were included, of which 4 653 were related to Leonurus, 1 017 were Chinese patent medicine, 648 were raw material medicine, and 722 were veterinary medicine.The amount of literature on Chinese patent medicine related to Leonurus chinensis increased in three stages, and the top 12 journals were all Chinese periodicals. The first three formulations of Chinese patent medicine were granule / granule, injection and capsule respectively.263 articles of Leonurus injection were reported in the literature of traditional Chinese patent medicine, including 48 basic studies, including uterine contraction, reduction of whole blood viscosity, improvement of myocardial ischemia and reperfusion injury, improvement of lymphatic microcirculation, and 211 clinical studies.Involved in postpartum hemorrhage and post-abortion bleeding, coronary heart disease, cerebral infarction, heart failure, myocardial ischemia and so on.Conclusion the literature of Chinese patent medicine of Leonurus chinensis is much less than that of traditional Chinese medicine decoction.Granule and injection may be the dominant dosage form of Leonurus in clinical use.Postpartum hemorrhage may be the dominant disease of Leonurus injection in clinical use.Leonurus injection has a variety of pharmacological effects, but the evidence level of clinical research literature is low, it is urgent to further develop high quality clinical research, and provide high quality evidence for clinical practice of Leonurus injection.
【作者单位】：四川大学华西医院中国循证医学中心;成都中医药大学公共卫生学院;四川大学华西基础医学与法医学院生物医学工程研究室;四川大学华西临床医学院;
【基金】：四川省科技计划项目(编号:2014SZ0139) 四川省教育厅自然科学一般项目(编号:132130320)
【分类号】：R282.71;G353.1

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